Alterations in serum paraoxonase-1 activity and lipid profile in chronic alcoholic patients infected with Strongyloides stercoralis
| Autor: | Mônica L. S. Silva, Elizabete de Jesus Inês, Joelma Nascimento de Souza, Alana Alcântara Galvão, Márcia Cristina Aquino Teixeira, Neci Matos Soares |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Hydrocortisone Veterinary (miscellaneous) 030231 tropical medicine Blood lipids Physiology Strongyloides stercoralis 03 medical and health sciences 0302 clinical medicine Blood serum medicine Animals Humans biology medicine.diagnostic_test Aryldialkylphosphatase business.industry Paraoxonase Middle Aged medicine.disease biology.organism_classification PON1 Alcoholism Cholesterol 030104 developmental biology Infectious Diseases Strongyloidiasis Case-Control Studies Insect Science Immunology Strongyloides biology.protein Female lipids (amino acids peptides and proteins) Parasitology Lipid profile business Brazil |
| Zdroj: | Acta Tropica. 166:1-6 |
| ISSN: | 0001-706X |
| DOI: | 10.1016/j.actatropica.2016.10.013 |
| Popis: | The objective of this study was to investigate paraoxonase-1 (PON1) activity, cortisol levels, and the lipid profile in the sera of alcoholic and non-alcoholic Strongyloides stercoralis-infected and uninfected individuals in a sample of 276 individuals attended at the National Health System in Salvador, Bahia, Brazil. The activity of PON1 was measured by the Beltowski method, serum lipids, and cortisol levels using commercial kits. PON1 activity was low in both alcoholic and non-alcoholic individuals infected with S. stercoralis. A positive correlation was observed between PON1 activity and cortisol concentration in alcoholic individuals who were not infected with S. stercoralis; whereas a negative correlation occurred in S. stercoralis-infected nonalcoholic individuals. The levels of triglycerides, LDL-C, and VLDL-C in S. stercoralis-infected alcoholic individuals were significantly lower than in uninfected alcoholic individuals. The high level of HDL-C and the low level of LDL-C, VLDL, triglycerides and PON1 activity in alcoholic patients infected with S. stercoralis evidenced an anti-atherogenic pattern. |
| Databáze: | OpenAIRE |
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