| Autor: |
Roman A. Barmin, Elizaveta A. Maksimova, Polina G. Rudakovskaya, Alexey V. Gayer, Evgeny A. Shirshin, Kirill S. Petrov, Daria A. Terentyeva, Olga I. Gusliakova, Olga A. Sindeeva, Oleg A. Klimenko, Roman N. Chuprov-Netochin, Alexander A. Solovev, Gaoshan Huang, Anastasia V. Ryabova, Victor B. Loschenov, Dmitry A. Gorin |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Colloids and surfaces. B, Biointerfaces. 219 |
| ISSN: |
1873-4367 |
| Popis: |
Gas-liquid interfaces are reaching a particular interest in biomedicine. Microbubbles, ultrasound contrast agents of clinical routine, gained increasing attention as theranostic platforms due to the preserved acoustic response, drug conjugation capabilities, and applicability in biological barrier opening. A combination of microbubbles and photodynamic therapy agents can enhance the photodynamic effect, yet the evaluation of agent conjugation on microbubble stabilization and photodynamic effect is needed. Hence, two commercially available phthalocyanine photosensitizers - Holosens® (ZnPc) and Photosens® (AlPc) - were coupled with bovine serum albumin before microbubble synthesis. We demonstrated an albumin: phthalocyanine ratio of 1:1 and covalent attachment for ZnPc, a ratio of 1:3 with electrostatic binding for AlPc. Submicron-sized microbubbles (air- and SF |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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