Usefulness of Heart-Type Fatty Acid-Binding Protein and Myocardial Performance Index for Early Detection of 5-Fluorouracil Cardiotoxicity
| Autor: | Ahmet Çağrı Aykan, Mustafa Tarık Ağaç, İlker Gül, Turhan Turan, Ramazan Akdemir, Şükrü Çelik, Hakan Erkan, Ercüment Cengiz, Faruk Boyacı, Tayyar Gökdeniz, Ali Rıza Akyüz, Selim Kul |
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| Přispěvatelé: | Turan, T, Agac, MT, Aykan, AC, Kul, S, Akyuz, AR, Gokdeniz, T, Gul, I, Cengiz, E, Boyaci, F, Erkan, H, Akdemir, R, Celik, S, Sakarya Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri Bölümü, Ağaç, Mustafa Tarık, Akdemir, Ramazan |
| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Ischemia Myocardial Ischemia 030204 cardiovascular system & hematology Fatty Acid-Binding Proteins Fatty acid-binding protein 03 medical and health sciences 0302 clinical medicine Internal medicine Troponin I medicine Humans Aged Cardiotoxicity Chemotherapy business.industry Middle Aged medicine.disease Early Diagnosis Fluorouracil Echocardiography 030220 oncology & carcinogenesis Coronary vasospasm Heart-type fatty acid binding protein Cardiovascular System & Cardiology Cardiology Female Cardiology and Cardiovascular Medicine business Biomarkers medicine.drug |
| Zdroj: | Angiology. 68(1) |
| ISSN: | 1940-1574 |
| Popis: | In the present study, we aimed to evaluate temporal changes in heart-type fatty acid-binding protein (h-FABP) and myocardial performance index (Tei index) following administration of 5-fluorouracil (5-FU), a chemotherapeutic agent associated with myocardial ischemia induced by coronary vasospasm. Thirty-two patients with cancer receiving their first 5-FU-based chemotherapy were included in the study. Prior to chemotherapy and 24 hours after the initiation of chemotherapy, all patients underwent a comprehensive echocardiographic examination. Blood samples were taken for h-FABP and troponin I (TnI) measurements at different time points during the first 24 hours of 5-FU administration. Postinfusion echocardiography revealed worsening in Tei index (0.37 ± 0.08 vs 0.43 ± 0.07, P < .001). Clinically overt cardiotoxicity was evident in 4 (12.5%) of our patient population. Heart-type fatty acid binding protein and TnI levels were within normal ranges at all time points. Our results suggest that ischemia coronary vasospasm due to 5-FU cardiotoxicity should be reviewed. Furthermore, Tei index might be a sensitive indicator of occult 5-FU cardiotoxicity. |
| Databáze: | OpenAIRE |
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