Strontium Ranelate Elevates Expression of Heme Oxygenase-1 and Decreases Alveolar Bone Loss in Rats
| Autor: | Rodrigo Maranguape Silva da Cunha, Francisco Isaac Fernandes Gomes, Paula Goes Pinheiro Dutra, Karuza Maria Alves Pereira, Hellíada Vasconcelos Chaves, Ricardo Basto Souza, Mirna Marques Bezerra |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
inorganic chemicals musculoskeletal diseases medicine.medical_specialty Bone resorption 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Strontium ranelate Internal medicine medicine Heme periodontitis Dental alveolus Periodontitis Original Paper business.industry Diphosphonates 030206 dentistry heme oxygenase medicine.disease Heme oxygenase lcsh:RK1-715 030104 developmental biology Endocrinology chemistry lcsh:Dentistry diphosphonates business bone resorption medicine.drug |
| Zdroj: | Journal of Oral & Maxillofacial Research eJournal of Oral Maxillofacial Research, Vol 9, Iss 4, p e4 (2018) |
| ISSN: | 2029-283X |
| Popis: | Objectives The purpose of this study was to determine the effects of strontium ranelate on ligature-induced periodontitis in rats and assess the putative involvement of heme oxygenase-1 (HO-1) pathway in these effects. Material and Methods Male Wistar rats underwent nylon ligature placement around maxillary molars and were treated (v.o.) with strontium ranelate (20 or 100 mg/kg) for 7 days. After that, rats were euthanized and histomorphometric/histopathological analyses and RT-PCR for HO-1 expression were performed. Results Strontium ranelate (20 or 100 mg/kg) prevented bone resorption by 28% and 38%, respectively. Strontium ranelate treatment (100 mg/kg) up-regulated (P < 0.05) heme oxygenase-1 mRNA levels in the gingival tissues in comparison to control groups. Conclusions Strontium ranelate prevented periodontal bone loss in experimental periodontitis in rats while heme oxygenase-1 mRNA levels increased after treatment. |
| Databáze: | OpenAIRE |
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