Comparison of Brain Natriuretic Peptide Plasma Levels Versus Logistic EuroSCORE in Predicting In-Hospital and Late Postoperative Mortality in Patients Undergoing Aortic Valve Replacement for Symptomatic Aortic Stenosis
| Autor: | Francesco Siclari, Francesco Faletra, Serge Masson, Elena Pasotti, Angelo Auricchio, Maria Grazia Rossi, Roberto Latini, Fabrizio Minervini, Giovanni Pedrazzini, Catherine Klersy, Tiziano Moccetti |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Aortic valve medicine.medical_specialty Coronary Artery Disease Severity of Illness Index Aortic valve replacement Interquartile range Internal medicine Natriuretic Peptide Brain Outcome Assessment Health Care Preoperative Care Humans Medicine Hospital Mortality Prospective Studies Heart valve Coronary Artery Bypass Aged Ejection fraction business.industry Age Factors Aortic Valve Stenosis Perioperative Brain natriuretic peptide medicine.disease Cardiac surgery medicine.anatomical_structure Aortic Valve Heart Valve Prosthesis cardiovascular system Cardiology Female Cardiology and Cardiovascular Medicine business Follow-Up Studies |
| Zdroj: | The American Journal of Cardiology. 102:749-754 |
| ISSN: | 0002-9149 |
| DOI: | 10.1016/j.amjcard.2008.04.055 |
| Popis: | The accuracy of the logistic EuroSCORE (logES), a widely used risk prediction algorithm for cardiac surgery including aortic valve surgery, usually overestimates observed perioperative mortality. Elevated brain natriuretic peptide (BNP) in symptomatic patients with aortic stenosis (AS) is associated with a poor short-term outcome after aortic valve replacement. We aimed to compare BNP with the logES for predicting short- and long-term outcome in symptomatic patients with severe AS undergoing aortic valve replacement. We prospectively studied 144 consecutive patients referred for aortic valve replacement (42% women, 73 +/- 9 years, mean aortic gradient 51 +/- 18 mm Hg, and left ventricular ejection fraction 61 +/- 11%) undergoing either isolated aortic valve replacement (58%) or combined to bypass grafting. Both plasma BNP and logES was estimated before surgery. The median BNP plasma level and logES were 157 pg/ml (interquartile range [IQR] 61 to 440) and 6.6% (IQR 4.2 to 12.2), respectively. The perioperative mortality was 6% and the overall mortality by the end of the study was 13%. Patients with logES >10.1% (upper tertile) had a higher risk of dying over time (hazard ratio [HR] 2.86, p = 0.037), as had patients with BNP >312 pg/ml (HR 9.01, p |
| Databáze: | OpenAIRE |
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