Effects of glucagon-like peptide 1 on appetite and body weight: focus on the CNS
| Autor: | M. Diamant, L van Bloemendaal, Richard G. IJzerman, J S ten Kulve, S E la Fleur |
|---|---|
| Přispěvatelé: | Internal medicine, NCA - Neurobiology of mental health, ICaR - Circulation and metabolism |
| Rok vydání: | 2014 |
| Předmět: |
Central Nervous System
medicine.medical_specialty endocrine system Endocrinology Diabetes and Metabolism media_common.quotation_subject Appetite Type 2 diabetes Biology Endocrinology Weight loss Glucagon-Like Peptide 1 Internal medicine medicine Ingestion Animals Humans media_common Liraglutide Gastric distension digestive oral and skin physiology Body Weight medicine.disease Glucagon-like peptide-1 Diabetes Mellitus Type 2 medicine.symptom Exenatide hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | van Bloemendaal, L, ten Kulve, J S, la Fleur, S E, IJzerman, R G & Diamant, M 2014, ' Effects of glucagon-like peptide 1 on appetite and body weight: focus on the CNS ', Journal of Endocrinology, vol. 221, no. 1, pp. T1-T16 . https://doi.org/10.1530/JOE-13-0414 Journal of Endocrinology, 221(1), T1-T16. Society for Endocrinology |
| ISSN: | 0022-0795 |
| Popis: | The delivery of nutrients to the gastrointestinal tract after food ingestion activates the secretion of several gut-derived mediators, including the incretin hormone glucagon-like peptide 1 (GLP-1). GLP-1 receptor agonists (GLP-1RA), such as exenatide and liraglutide, are currently employed successfully in the treatment of patients with type 2 diabetes mellitus. GLP-1RA improve glycaemic control and stimulate satiety, leading to reductions in food intake and body weight. Besides gastric distension and peripheral vagal nerve activation, GLP-1RA induce satiety by influencing brain regions involved in the regulation of feeding, and several routes of action have been proposed. This review summarises the evidence for a physiological role of GLP-1 in the central regulation of feeding behaviour and the different routes of action involved. Also, we provide an overview of presently available data on pharmacological stimulation of GLP-1 pathways leading to alterations in CNS activity, reductions in food intake and weight loss. |
| Databáze: | OpenAIRE |
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