Treatment of the primary in metastatic prostate cancer
| Autor: | Axel Heidenreich, Andrei Andresanu, Catalin Baston, C Gîngu, Adrian Mihancea, Ioanel Sinescu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Oncology
Male medicine.medical_specialty Urology medicine.medical_treatment 030232 urology & nephrology Antineoplastic Agents Androgen deprivation therapy 03 medical and health sciences Prostate cancer chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Combined Modality Therapy Humans Neoplasm Metastasis Prostatectomy business.industry Standard treatment Abiraterone acetate Prostatic Neoplasms Androgen Antagonists medicine.disease Neoadjuvant Therapy Radiation therapy Docetaxel chemistry 030220 oncology & carcinogenesis Radiotherapy Adjuvant business medicine.drug |
| Zdroj: | Current opinion in urology. 30(4) |
| ISSN: | 1473-6586 |
| Popis: | Purpose of review The standard treatment in metastatic prostate cancer (mPCa) is systemic, based on androgen deprivation therapy recommended in different forms, alone or combined with abiraterone acetate or docetaxel. The aim of this review is to synthesize the available data from literature regarding the optimal treatment of the primary in patients diagnosed with metastatic prostate cancer. Recent findings Multimodal treatments offer the best chance for survival for these patients, but the optimal strategy lacks consensus. Using retrospective studies as an argument, recent articles sustain the clinical and oncological benefits of local therapies in hormone-naive metastatic prostate cancer, represented by radical prostatectomy or radiotherapy. Through these procedures, local control of disease can be achieved, thus avoiding potential complications and further surgical interventions. Even if the current results are not evenly relevant, the treatment of the primary along with metastasis-directed therapy could improve survival and even cure-selected patients. Summary This article emphasizes important aspects regarding a feasible management of mPCa, with possible impact on subsequent guidelines. The expected results from ongoing trials may provide another perspective in treatment of these cases. |
| Databáze: | OpenAIRE |
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