A compromised developmental trajectory of the infant gut microbiome and metabolome in atopic eczema

Autor: Jia Yun Woon, Keith M. Godfrey, Oon Hoe Teoh, Lynette Pei-Chi Shek, Jan Knol, Dorinda Yan Qin Kioh, Neerja Karnani, Hugo Van Bever, Anne Goh, Staffan Kjelleberg, Evelyn Xiu Ling Loo, Le Duc Huy Ta, Rikky W. Purbojati, Gaik Chin Yap, Stephan C. Schuster, Yanqing Michelle Koh, Fabian Yap, Daniela I. Drautz-Moses, Eric Chun Yong Chan, James Chun Yip Chan, Elizabeth Huiwen Tham, Carina Jing Xuan Tay, Yap Seng Chong, Yiong Huak Chan, Kok Hian Tan, Christophe Lay, Chiung-Hui Huang, Bee Wah Lee
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Male
Allergy
Bacteroidaceae
atopic eczema
gut microbiome
gut metabolome
allergen sensitization
Feces
0302 clinical medicine
early life
Longitudinal Studies
chemistry.chemical_classification
atopic dermatitis
Gastroenterology
Atopic dermatitis
Butyrates
Infectious Diseases
Metabolome
Carbohydrate Metabolism
030211 gastroenterology & hepatology
Female
Bacteroides fragilis
Glycolysis
Research Article
Research Paper
Microbiology (medical)
Virulence Factors
Virulence
Butyrate
Biology
Microbiology
Early life
Dermatitis
Atopic
03 medical and health sciences
Enterobacteriaceae
scfa
medicine
Humans
Microbiome
MolEco
lcsh:RC799-869
VLAG
Infant
Newborn
Infant
Allergens
medicine.disease
biology.organism_classification
SCFA
Fatty Acids
Volatile
Gastrointestinal Microbiome
Gastrointestinal Tract
030104 developmental biology
Glucose
chemistry
Propionate
lcsh:Diseases of the digestive system. Gastroenterology
Propionates
Transcriptome
Zdroj: Gut Microbes, Vol 12, Iss 1 (2020)
Gut Microbes
article-version (VoR) Version of Record
Gut Microbes 12 (2020) 1
Gut Microbes, 12(1), 1-21
ISSN: 1949-0984
1949-0976
Popis: Evidence is accumulating that the establishment of the gut microbiome in early life influences the development of atopic eczema. In this longitudinal study, we used integrated multi-omics analyses to infer functional mechanisms by which the microbiome modulates atopic eczema risk. We measured the functionality of the gut microbiome and metabolome of 63 infants between ages 3 weeks and 12 months with well-defined eczema cases and controls in a sub-cohort from the Growing Up in Singapore Toward healthy Outcomes (GUSTO) mother-offspring cohort. At 3 weeks, the microbiome and metabolome of allergen-sensitized atopic eczema infants were characterized by an enrichment of Escherichia coli and Klebsiella pneumoniae, associated with increased stool D-glucose concentration and increased gene expression of associated virulence factors. A delayed colonization by beneficial Bacteroides fragilis and subsequent delayed accumulation of butyrate and propionate producers after 3 months was also observed. Here, we describe an aberrant developmental trajectory of the gut microbiome and stool metabolome in allergen sensitized atopic eczema infants. The infographic describes an impaired developmental trajectory of the gut microbiome and metabolome in allergen-sensitized atopic eczema (AE) infants and infer its contribution in modulating allergy risk in the Singaporean mother-offspring GUSTO cohort. The key microbial signature of AE is characterized by (1) an enrichment of Escherichia coli and Klebsiella pneumoniae which are associated with accumulation of pre-glycolysis intermediates (D-glucose) via the trehalose metabolic pathway, increased gene expression of associated virulence factors (invasin, adhesin, flagellin and lipopolysaccharides) by utilizing ATP from oxidative phosphorylation and delayed production of butyrate and propionate, (2) depletion of Bacteroides fragilis which resulted in lower expression of immunostimulatory bacterial cell envelope structure and folate (vitamin B9) biosynthesis pathway, and (3) accompanied depletion of bacterial groups with the ability to derive butyrate and propionate through direct or indirect pathways which collectively resulted in reduced glycolysis, butyrate and propionate biosynthesis.
Graphical abstract
Databáze: OpenAIRE
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