Diagnostic value of STMN1, LMO2, HGAL, AID expression and 1p36 chromosomal abnormalities in primary cutaneous B cell lymphomas

Autor: Ariane Tempier, Olivier Dereure, Luc Durand, Céline René, Vanessa Szablewski, Assia Benammar-Hafidi, Isabelle Gazagne, Mathieu Gallo, Evelyne Verdanet, Valère Cacheux, Eric Frouin, Valérie Costes-Martineau
Přispěvatelé: Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Université de Montpellier (UM), Pathogénèse et contrôle des infections chroniques (PCCI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre Hospitalier Universitaire de Montpellier (CHU Montpellier ), Centre hospitalier universitaire de Poitiers (CHU Poitiers), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Montpellier (CHU Montpellier )-Université de Montpellier (UM)
Rok vydání: 2017
Předmět:
Male
0301 basic medicine
Pathology
Skin Neoplasms
[SDV]Life Sciences [q-bio]
Follicular lymphoma
Cutaneous Follicular Lymphoma
Cutaneous lymphoma
0302 clinical medicine
immune system diseases
hemic and lymphatic diseases
B-cell lymphoma
Lymphoma
Follicular
Aged
80 and over
Microfilament Proteins
MNDA
Intracellular Signaling Peptides and Proteins
General Medicine
LIM Domain Proteins
Middle Aged
Prognosis
BCL6
Neoplasm Proteins
cytogenetic alteration
3. Good health
Proto-Oncogene Proteins c-bcl-2
Chromosomes
Human
Pair 1
030220 oncology & carcinogenesis
Chromosomal region
Proto-Oncogene Proteins c-bcl-6
Primary cutaneous marginal zone lymphoma
Female
Chromosome Deletion
Adult
medicine.medical_specialty
Lymphoma
B-Cell
Histology
Biology
Pathology and Forensic Medicine
03 medical and health sciences
Cytidine Deaminase
Proto-Oncogene Proteins
Biomarkers
Tumor
medicine
Humans
1p36 chromosomal deletion
cutaneous lymphoma
Adaptor Proteins
Signal Transducing
Aged
STMN1
Lymphoma
B-Cell
Marginal Zone
medicine.disease
030104 developmental biology
Stathmin
Zdroj: Histopathology
Histopathology, Wiley, 2017, 71 (4), pp.648--660. ⟨10.1111/his.13279⟩
ISSN: 0309-0167
1365-2559
Popis: International audience; Distinction between primary cutaneous follicular lymphoma (PCFL) and primary cutaneous marginal zone lymphoma (PCMZL) is challenging, as clear-cut immunophenotypical and cytogenetic criteria to segregate both entities are lacking. METHODS AND RESULTS: To characterize PCFL and PCMZL more clearly and to define criteria helpful for the differential diagnosis, we compared expression of immunohistochemical markers [LIM-only transcription factor 2 (LMO2), human germinal centre-associated lymphoma (HGAL), stathmin 1 (STMN1), activation-induced cytidine deaminase (AID), myeloid cell nuclear differentiation antigen (MNDA)] and the presence of cytogenetic abnormalities described previously in nodal follicular lymphoma [B cell lymphoma 2 (BCL2) and BCL6 breaks, 1p36 chromosomal region deletion (del 1p36)] in a series of 48 cutaneous follicular and marginal zone lymphomas [cutaneous follicular lymphoma (CFL) and cutaneous marginal zone lymphoma (CMZL)]. Immunostaining for STMN1, LMO2, HGAL and AID allowed the distinction between CFL and CMZL, and STMN1 was the most sensitive marker (100% CFL, 0% CMZL). LMO2, HGAL and AID were positive in 93.2%, 82.1% and 86.2% CFL (all CMZL-negative). MNDA was expressed in both entities without significant difference (10.3% CFL, 30.8% CMZL, P = 0.18). BCL2, BCL6 breaks and the del 1p36 were present in 16.7%, 10.7% and 18.5% CFL and no CMZL. Finally, three and 29 CFL were reclassified as secondary cutaneous follicular lymphomas (SCFL) and PCFL without significant differences concerning phenotypical and cytogenetic features. BCL2, BCL6 breaks and the del 1p36 were present in 11.1%, 8% and 16.7% PCFL and did not impact the prognosis. CONCLUSION: LMO2, HGAL, STMN1 and AID, but not MNDA, are discriminant for the recognition between CFL and CMZL. BCL2, BCL6 rearrangements and the del 1p36 have a role in the pathogenesis of PCFL, the latest being the most common alteration.
Databáze: OpenAIRE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje