Seroepidemiology of Dengue, Zika, and Yellow Fever Viruses among Children in the Democratic Republic of the Congo
| Autor: | Dieudonné Mumba, Melchior Kashamuka, Aravinda M. de Silva, Antoinette Tshefu, Ramesh Jadi, Corinna Keeler, Jonathan B. Parr, Alexandra C. Willcox, Matthew H. Collins, Steven R Meshnick |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
030231 tropical medicine
Population Antibodies Viral Dengue fever Dengue 03 medical and health sciences 0302 clinical medicine Seroepidemiologic Studies Virology Yellow Fever medicine Seroprevalence Humans 030212 general & internal medicine education education.field_of_study biology business.industry Zika Virus Infection Yellow fever Yellow Fever Vaccine Outbreak Infant Articles Zika Virus Dengue Virus medicine.disease biology.organism_classification Vaccination Flavivirus Infectious Diseases Child Preschool Democratic Republic of the Congo Parasitology Yellow fever virus business Malaria |
| Popis: | Flaviviruses such as Zika, dengue, and yellow fever cause epidemics throughout the tropics and account for substantial global morbidity and mortality. Although malaria and other vector-borne diseases have long been appreciated in Africa, flavivirus epidemiology is incompletely understood. Despite the existence of an effective vaccine, yellow fever continues to cause outbreaks and deaths, including at least 42 fatalities in the Democratic Republic of the Congo (DRC) in 2016. Here, we leveraged biospecimens collected as part of the nationally representative 2013-2014 Demographic and Health Survey in the DRC to examine serological evidence of flavivirus infection or vaccination in children aged 6 months to 5 years. Even in this young stratum of the Congolese population, we find evidence of infection by dengue and Zika viruses based on results from enzyme-linked immunosorbent assay and neutralization assay. Surprisingly, there was remarkable discordance between reported yellow fever vaccination status and results of serological assays. The estimated seroprevalences of neutralizing antibodies against each virus are yellow fever, 6.0% (95% confidence interval [CI] = 4.6-7.5%); dengue, 0.4% (0.1-0.9%); and Zika, 0.1% (0.0-0.5%). These results merit targeted, prospective studies to assess effectiveness of yellow fever vaccination programs, determine flavivirus seroprevalence across a broader age range, and investigate how these emerging diseases contribute to the burden of acute febrile illness in the DRC. |
| Databáze: | OpenAIRE |
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