Development of transient thyroid disease and reaction during treatment of chronic hepatitis C with interferon
| Autor: | Shigeo Katabami, Kentaro Yamashita, Naoki Azuma, Akio Katanuma, Keiichi Kamijo, Tomohiro Tamaki, Toshinori Kodama, Akira Yachi |
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| Rok vydání: | 1994 |
| Předmět: |
Male
Thyroid Hormones Thyroiditis endocrine system medicine.medical_specialty endocrine system diseases Interferon alpha-2 Autoimmune thyroiditis Hypothyroidism Internal medicine medicine Humans Autoantibodies Hepatitis Chronic Subclinical infection business.industry Thyroid disease Thyroid Thyroiditis Autoimmune Gastroenterology Interferon-alpha medicine.disease Hepatitis C Recombinant Proteins Anti-thyroid autoantibodies Endocrinology medicine.anatomical_structure Interferon Type I Female Thyroid function business Hormone |
| Zdroj: | Journal of Gastroenterology. 29:289-292 |
| ISSN: | 1435-5922 0944-1174 |
| Popis: | Six of 50 (12%) patients with chronic hepatitis C who were treated with interferon developed thyroid disease or an autoimmune thyroid reaction while undergoing treatment. One patient developed silent thyroiditis, with an increase in serum tri-iodothyronine (T3), thyroxine (T4), free T3, free T4, and markedly suppressed thyroid-stimulating hormone (TSH) levels, accompanied by the appearance of both antithyroglobulin (TgAb) and antimicrosomal antibodies (McAb). One patient developed hypothyroidism in association with moderately elevated TSH levels and high titers of McAb. TSH, TgAb, and McAb levels returned to the initial values at least 4 months after the end of interferon treatment (9 months of follow up). Four patients whose TgAb and/or McAb levels were elevated during treatment with interferon had been diagnosed as having subclinical autoimmune thyroiditis; however, their thyroid function remained in the normal range. These results suggested that treatment with interferon can cause a transient autoimmune thyroid reaction and disease as a side effect. |
| Databáze: | OpenAIRE |
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