Emergence of CD26+ Cancer Stem Cells with Metastatic Properties in Colorectal Carcinogenesis
| Autor: | Roberta Pang, Hung-Sing Lee, Wai Lun Law, Ariel K.M. Chow, Lui Ng, Timothy Ming-Hun Wan, Colin S.C. Lam, Johnny Hon Wai Man, Ronnie T.P. Poon, SK Wong, Alvin K.H. Cheung, Deepak Narayanan Iyer |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
CA15-3 Male cancer stem cells Pathology medicine.medical_specialty Carcinogenesis Dipeptidyl Peptidase 4 Tumor M2-PK colorectal cancer Biology Catalysis Article Metastasis Inorganic Chemistry lcsh:Chemistry 03 medical and health sciences 0302 clinical medicine Cancer stem cell medicine Biomarkers Tumor Humans metastasis Physical and Theoretical Chemistry Molecular Biology lcsh:QH301-705.5 Spectroscopy Aged CD26 Aged 80 and over Organic Chemistry Cancer General Medicine medicine.disease Primary tumor Computer Science Applications 030104 developmental biology lcsh:Biology (General) lcsh:QD1-999 030220 oncology & carcinogenesis Cancer cell Neoplastic Stem Cells Female Stem cell Colorectal Neoplasms |
| Zdroj: | International Journal of Molecular Sciences, Vol 18, Iss 6, p 1106 (2017) International Journal of Molecular Sciences International Journal of Molecular Sciences; Volume 18; Issue 6; Pages: 1106 |
| ISSN: | 1422-0067 |
| Popis: | Colorectal cancer results from genetic aberrations which accumulate over a long period of time, with malignant and metastatic properties acquired at a relatively late stage. A subpopulation of CD26+ colorectal cancer stem cells are known to be implicated in metastasis. We quantified CD26+ cancer cells in 11 primary tumor samples by flow cytometry, and showed that tumors having confirmed or suspected metastases harbored a relatively high CD26+ level in these samples. We hypothesized that this subpopulation of cancer stem cells arises in the late stage of carcinogenesis from the bulk of tumor daughter cells which are CD26−. The manipulation of PIK3CA and TP53, two genes commonly deregulated in the late stage, had an effect on the maintenance of the CD26+ cell population. When CD26− tumor daughter cells were sorted and cultured, the emergence of tumor spheres containing CD26+ cells occurred. These findings shed light to the origin of colorectal cancer stem cells with metastatic properties, which has an implication on conventional treatments by surgery or adjuvant chemotherapy for tumor debulking. |
| Databáze: | OpenAIRE |
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