Vaginal clear cell carcinoma in a young patient with ectopic termination of the left ureter in the vagina
Autor: | Justus Müller, Gruss A, Hans Konrad Müller-Hermelink, Steck T, Martius J, Rehn M, M. Michaela Ott |
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Rok vydání: | 1994 |
Předmět: |
medicine.medical_specialty
Pathology Vaginal Neoplasms Adolescent Vaginal adenosis Vaginal Diseases Diethylstilbestrol Choristoma Pathology and Forensic Medicine Vaginal disease Biomarkers Tumor Medicine Humans Clear-cell adenocarcinoma Molecular Biology Gynecology business.industry Nuclear Proteins Cell Biology General Medicine medicine.disease Immunohistochemistry Hypoplasia Carcinoembryonic Antigen Neoplasm Proteins medicine.anatomical_structure Ki-67 Antigen Receptors Estrogen Clear cell carcinoma Vagina Keratins Clear-cell adenocarcinoma of the vagina Female Ureter business Receptors Progesterone medicine.drug Adenocarcinoma Clear Cell |
Zdroj: | Virchows Archiv : an international journal of pathology. 425(4) |
ISSN: | 0945-6317 |
Popis: | The association of clear cell adenocarcinoma of the vagina and vaginal adenosis with prenatal exposure to diethylstilbestrol (DES) is well-documented in the United States. In Europe, however, DES was never used in the therapy of threatened abortion and, therefore, clear cell adenocarcinoma and vaginal adenosis remained rare diseases. We report on the clinical and pathological features of a case of clear cell adenocarcinoma of the upper vagina in a 17-year-old German girl, who had a history of hypoplasia of the left kidney with an ectopic termination of the ureter in the upper vagina, removed surgically 2 years before. No previous report of a similar coincidence of vaginal clear cell carcinoma and a congenital disorder of the genitourinary tract exists. Congenital anomaly of the ureter interfering with the development and the differentiation of the distal Mullerian tract and its epithelium might have provided a similar histological basis for carcinogenesis in our patient to that in those provided exposed to DES. |
Databáze: | OpenAIRE |
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