Prognostic value of B-cell linker protein in colorectal cancer
Autor: | Byung Kyu Ahn, Seung Sam Paik, Kang Hong Lee, Ju Hee Lee, Jun Ho Lee |
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Rok vydání: | 2020 |
Předmět: |
Male
0301 basic medicine medicine.medical_specialty Colorectal cancer Perineural invasion Adenocarcinoma Gastroenterology Disease-Free Survival Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Internal medicine Biomarkers Tumor medicine Humans Survival rate Adaptor Proteins Signal Transducing Aged Tissue microarray business.industry Hazard ratio Cell Biology Middle Aged Prognosis medicine.disease 030104 developmental biology 030220 oncology & carcinogenesis Immunohistochemistry Female Colorectal Neoplasms B-Cell Linker Protein business |
Zdroj: | Pathology - Research and Practice. 216:152821 |
ISSN: | 0344-0338 |
DOI: | 10.1016/j.prp.2020.152821 |
Popis: | This study aimed to investigate the clinicopathological and prognostic impact of B-cell linker (BLNK) protein expression in colorectal cancer (CRC) as its function in CRC remains unexplored. We performed immunohistochemical staining for BLNK using tissue microarrays of 418 consecutive CRC samples; of these 10 were excluded due to inappropriate staining. The expression intensity and staining level was scored as 0-3 and 0-4, respectively, based on the percentage of positive cells. The immunoreactivity score (IRS) was calculated by multiplying these two scores. BLNK expression was observed in 222 patients (54.4 %). Lymph node metastasis (p = 0.031), right colon cancer (p = 0.026), mucinous adenocarcinoma (p < 0.001), and perineural invasion (p = 0.049) were more frequently observed in the IRS 4-12 group than in the IRS 0-3 group. At the same cutoff point, the 5-year recurrence-free survival rate of the patients with stage III was significantly lower than that observed in IRS 4-12 group (74.8 % ± 4.2 % vs. 54.2 % ± 8.5 %, p = 0.003). Multivariate analysis revealed IRS 4-12 to be an independent risk factor for recurrence (Hazard ratio 2.346, 95 % confidence interval 1.348-4.085, p = 0.003). In conclusion, overexpression of BLNK protein is an independent risk factor for CRC recurrence. |
Databáze: | OpenAIRE |
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