Activation of Vibrio cholerae quorum sensing promotes survival of an arthropod host

Autor: Paula I. Watnick, Adam C. N. Wong, Afsar Ali, Layla Kamareddine, Katharine Kierek-Pearson, J. Glenn Morris, Alexandra E. Purdy, Saiyu Hang, Audrey S. Vanhove, John M. Asara
Rok vydání: 2017
Předmět:
0301 basic medicine
Succinic Acid
medicine.disease_cause
Applied Microbiology and Biotechnology
biofilm
Drosophila Proteins
Vibrio cholerae
Virulence
biology
quorum sensing
Organ Size
Cholera
Intestines
Drosophila melanogaster
Adipose Tissue
Gene Knockdown Techniques
Host-Pathogen Interactions
Female
Signal transduction
Signal Transduction
Microbiology (medical)
host-microbe interaction
Lipolysis
Immunology
Microbiology
Article
03 medical and health sciences
Bacterial Proteins
Somatomedins
Genetics
medicine
Animals
Arthropods
Triglycerides
Host (biology)
Gene Expression Profiling
Gene Expression Regulation
Bacterial
Cell Biology
biochemical phenomena
metabolism
and nutrition
succinate
medicine.disease
biology.organism_classification
Disease Models
Animal
Quorum sensing
030104 developmental biology
Biofilms
Arthropod
metabolism
Bacteria
Zdroj: Nature microbiology
ISSN: 2058-5276
DOI: 10.1038/s41564-017-0065-7
Popis: Vibrio cholerae colonizes the human terminal ileum to cause cholera, and the arthropod intestine and exoskeleton to persist in the aquatic environment. Attachment to these surfaces is regulated by the bacterial quorum-sensing signal transduction cascade, which allows bacteria to assess the density of microbial neighbours. Intestinal colonization with V. cholerae results in expenditure of host lipid stores in the model arthropod Drosophila melanogaster. Here we report that activation of quorum sensing in the Drosophila intestine retards this process by repressing V. cholerae succinate uptake. Increased host access to intestinal succinate mitigates infection-induced lipid wasting to extend survival of V. cholerae-infected flies. Therefore, quorum sensing promotes a more favourable interaction between V. cholerae and an arthropod host by reducing the nutritional burden of intestinal colonization.
Databáze: OpenAIRE
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