Molecular cloning and expression of the rat homologue of presenilin-1
| Autor: | Marc Mercken, Yuko Nakazato, Miyuki Murayama, Hiroshi Takahashi, Akihiko Takashima, Kazutomo Imahori, Kaori Noguchi |
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| Rok vydání: | 1996 |
| Předmět: |
Regulation of gene expression
Genetics Chromosomes Human Pair 14 Sequence Homology Amino Acid Genetic Linkage General Neuroscience Molecular Sequence Data Molecular cloning Biology Molecular biology Homology (biology) Presenilin Rats Transmembrane domain Mice Gene Expression Regulation Alzheimer Disease Gene expression Animals Humans Amino Acid Sequence Cloning Molecular Gene Peptide sequence |
| Zdroj: | Neuroscience letters. 206(2-3) |
| ISSN: | 0304-3940 |
| Popis: | The rat homologue of the presenilin-1 (PS-1) gene, which is responsible for early-onset familial Alzheimer's disease linked to chromosome 14, was cloned and sequenced. The predicted amino acid sequence showed quite high homology among rat, mouse, and human PS-1. Especially, the amino acid sequences of the putative transmembrane domains were highly conserved among the three species. The expression level of the PS-1 gene increased during brain development and the number of transcripts of the PS-1 gene changed during brain development. We found one transcript of the PS-1 gene in embryonic day 12 (E12)-E15 rat brain and two transcripts in E18-adult rat brain. Therefore, PS-1 may play a role in neurogenesis. |
| Databáze: | OpenAIRE |
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