Maternal consumption of artificially sweetened beverages during pregnancy is associated with infant gut microbiota and metabolic modifications and increased infant body mass index
| Autor: | Malcolm R. Sears, Laura K. Sycuro, Meghan B. Azad, Isabelle Laforest-Lapointe, Marie-Claire Arrieta, Theo J. Moraes, Allan B. Becker, Piushkumar J. Mandhane, Stuart E. Turvey, Padmaja Subbarao |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine obesity Pediatric Obesity breastfeeding Spermidine Succinic Acid Breastfeeding Physiology RC799-869 Gut flora Body Mass Index 0302 clinical medicine Pregnancy Prospective Studies 16s rRNA 2. Zero hunger biology Artificially Sweetened Beverages digestive oral and skin physiology Gastroenterology food and beverages Diseases of the digestive system. Gastroenterology metabolomics 3. Good health Infectious Diseases Prenatal Exposure Delayed Effects Female 030211 gastroenterology & hepatology Research Article Research Paper Microbiology (medical) Canada Gut microbiota artificial sweeteners Microbiology BMI 03 medical and health sciences Child cohort genomics medicine Humans Maternal consumption Infant gestational exposure medicine.disease biology.organism_classification Artificial Sweetener Obesity Gastrointestinal Microbiome 030104 developmental biology Increased risk Body mass index |
| Zdroj: | Gut Microbes article-version (VoR) Version of Record Gut Microbes, Vol 13, Iss 1 (2021) |
| ISSN: | 1949-0984 1949-0976 |
| Popis: | Artificial sweetener consumption by pregnant women has been associated with an increased risk of infant obesity, but the underlying mechanisms are unknown. We aimed to determine if maternal consumption of artificially sweetened beverages (ASB) during pregnancy is associated with modifications of infant gut bacterial community composition and function during the first year of life, and whether these alterations are linked with infant body mass index (BMI) at one year of age. We studied 100 infants from the prospective Canadian CHILD Cohort Study, selected based on maternal ASB consumption during pregnancy (50 non-consumers and 50 daily consumers). BMI was higher among ASB-exposed infants. Infant stool (16S rRNA gene sequencing) and urine (untargeted metabolomics) were acquired in early (3–4 months) and late (12 months) infancy. We identified four microbiome clusters, of which two recapitulated the maturation trajectory of the infant gut bacterial communities from immature (Cluster 1) to mature (Cluster 4) and two deviated from this trajectory (Clusters 2 and 3). Maternal ASB consumption did not differ between clusters, but was associated with community-level shifts in infant gut bacterial taxonomy structure and depletion of several Bacteroides sp. in Cluster 2. In the complete dataset, urine succinate and spermidine levels at 3 months were higher in ASB-exposed infants, and urine succinate was positively associated with BMI at one-year-old. Overall, gestational exposure to ASB was associated with gut microbiota structure in infants from Cluster 2, and gut microbiota structure was associated with infant BMI. Gestational exposure to ASB was positively associated with infant urine succinate and spermidine. Succinate was found to mediate 29% of the effect of ASB exposure on BMI at one-year-old, revealing a potential role of this metabolite in increased infant weight linked to gestational ASB consumption. As we face an unprecedented rise in childhood obesity, future studies should evaluate the causal relationships between maternal ASB consumption (a modifiable exposure), gut microbiota and metabolites, infant metabolism, and body composition. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|