Role of nitric oxide in the pathogenesis of alloxan diabetes
| Autor: | O. L. Terekhina, E. S. Boichuk, S. V. Kruglov, E. A. Smirnova, L. M. Belkina |
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| Rok vydání: | 2013 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty endocrine system diseases Nitric Oxide Nitroarginine General Biochemistry Genetics and Molecular Biology Nitric oxide Diabetes Mellitus Experimental Pathogenesis chemistry.chemical_compound Subcutaneous injection Internal medicine Alloxan Diabetes mellitus medicine Animals Nitrite Enzyme Inhibitors Rats Wistar Nitrites Type 1 diabetes Nitrates business.industry Rats Inbred Strains General Medicine medicine.disease Rats Endocrinology chemistry medicine.symptom Nitric Oxide Synthase business Polydipsia |
| Zdroj: | Bulletin of experimental biology and medicine. 154(5) |
| ISSN: | 1573-8221 |
| Popis: | We studied the effects of N(w)-nitro-L-arginine (L-NNA), a nonselective inhibitor of NO synthases, on the severity of type 1 diabetes mellitus induced by subcutaneous injection of 130 mg/kg alloxan in August rats with high activity of NO system and in Wistar rats. Five days after alloxan injection, hyperglycemia levels after overnight fasting in August and Wistar rats were 27.1±3.7 and 22.0±1.1 mmol/liter, respectively (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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