A Systematic Review of Metabolomic Biomarkers for the Intake of Sugar-Sweetened and Low-Calorie Sweetened Beverages
Autor: | Matthias Schmid, Anna Floegel, Kolade Oluwagbemigun, Ute Nöthlings, Jantje Goerdten, Samuel Muli |
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Rok vydání: | 2021 |
Předmět: |
Sucralose
Endocrinology Diabetes and Metabolism MEDLINE Review Microbiology Biochemistry chemistry.chemical_compound Metabolomics Environmental health Medicine Sugar Molecular Biology Saccharin business.industry biomarkers low-calorie sweetened beverages Sugar-sweetened beverages Biomarkers Low-calorie sweetened beverages metabolomics QR1-502 chemistry Biomarker (medicine) Observational study medicine.symptom business sugar-sweetened beverages Weight gain |
Zdroj: | Metabolites Metabolites, 11(8):546 Metabolites, Vol 11, Iss 546, p 546 (2021) |
ISSN: | 2218-1989 |
Popis: | Intake of added sugars (AS) is challenging to assess compared with total dietary sugar because of the lack of reliable assessment methods. The reliance on self-reported dietary data in observational studies is often cited as biased, with evidence of AS intake in relation to health outcomes rated as low to moderate quality. Sugar-sweetened beverages (SSBs) are a major source of AS. A regular and high intake of SSBs is associated with an overall poor diet, weight gain, and cardiometabolic risks. An elevated intake of low-calorie sweetened beverages (LCSBs), often regarded as healthier alternatives to SSBs, is also increasingly associated with increased risk for metabolic dysfunction. In this review, we systematically collate evidence and provide perspectives on the use of metabolomics for the discovery of candidate biomarkers associated with the intake of SSBs and LCSBs. We searched the Medline, Embase, Scopus, and Web of Science databases until the end of December 2020. Seventeen articles fulfilled our inclusion criteria. We evaluated specificity and validity of the identified biomarkers following Guidelines for Biomarker of Food Intake Reviews (BFIRev). We report that the 13C:12C carbon isotope ratio (δ13C), particularly, the δ13C of alanine is the most robust, sensitive, and specific biomarker of SSBs intake. Acesulfame-K, saccharin, sucralose, cyclamate, and steviol glucuronide showed moderate validity for predicting the short-term intake of LCSBs. More evidence is required to evaluate the validity of other panels of metabolites associated with the intake of SSBs. |
Databáze: | OpenAIRE |
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