The Role of Connexin 43 in Lung Disease
| Autor: | Ashlesh K. Murthy, Bruce J. Nicholson, Julie A. Swartzendruber |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
ARDS Cell type Connexin Inflammation Disease Review Bioinformatics General Biochemistry Genetics and Molecular Biology connexin 43 03 medical and health sciences 0302 clinical medicine medicine lcsh:Science Ecology Evolution Behavior and Systematics Asthma COPD Lung business.industry Paleontology respiratory system asthma acute respiratory distress syndrome medicine.disease respiratory tract diseases mitochondria 030104 developmental biology medicine.anatomical_structure Space and Planetary Science 030220 oncology & carcinogenesis gap junction proteins lcsh:Q sense organs medicine.symptom business |
| Zdroj: | Life, Vol 10, Iss 363, p 363 (2020) Life |
| ISSN: | 2075-1729 |
| Popis: | The term lung disease describes a broad category of disorders that impair lung function. More than 35 million Americans have a preventable chronic lung disease with high mortality rates due to limited treatment efficacy. The recent increase in patients with lung disease highlights the need to increase our understanding of mechanisms driving lung inflammation. Connexins, gap junction proteins, and more specifically connexin 43 (Cx43), are abundantly expressed in the lung and are known to play a role in lung diseases. This review focuses on the role of Cx43 in pathology associated with acute respiratory distress syndrome (ARDS), chronic obstructive pulmonary disease (COPD) and asthma. Additionally, we discuss the role of Cx43 in preventing disease through the transfer of mitochondria between cells. We aim to highlight the need to better understand what cell types are expressing Cx43 and how this expression influences lung disease. |
| Databáze: | OpenAIRE |
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