Intraspinal delivery of bone marrow stromal cell-derived neural stem cells in patients with amyotrophic lateral sclerosis: A safety and feasibility study
| Autor: | Nahid Beladimoghadam, Taki Tiraihi, Taher Taheri, Leili Chamani-Tabriz, Elham Faghihzadeh, Davoud Yadegarynia, Soghrat Faghihzadeh, Shahriar Nafissi, Mostafa Sadeghi, Abdollah Khanfakhraei, Hadi Kazemi |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Stromal cell Cell- and Tissue-Based Therapy Bone Marrow Cells Pulmonary function testing 03 medical and health sciences 0302 clinical medicine Humans Medicine Muscle Strength Amyotrophic lateral sclerosis Injections Spinal Aged Electromyography business.industry Amyotrophic Lateral Sclerosis Perioperative Middle Aged Evoked Potentials Motor medicine.disease Spinal cord Neural stem cell Surgery 030104 developmental biology medicine.anatomical_structure Neurology Feasibility Studies Female Neurology (clinical) Bone marrow Stem cell business 030217 neurology & neurosurgery |
| Zdroj: | Journal of the Neurological Sciences. 362:174-181 |
| ISSN: | 0022-510X |
| Popis: | Background Stem cells have been used in several studies with different methodologies to treat patients with ALS. Methods In this safety and feasibility study, 11 patients with definite or probable ALS according to El Escorial criteria were selected. 3 patients were excluded due to inadequate bone marrow or safety measures after acquisition of bone marrow. Bone marrow stromal cell-derived neural stem cells were injected in C7-T1 spinal cord under general anesthesia. Patients were followed for 12 months after injection with manual muscle testing, ALSFRS-R, quality of life changes, pulmonary function test and electromyography. Results None of the patients had perioperative mortality or major morbidity. One patient had temporary deterioration in lower extremities after injection which improved after a few weeks. In the 12 months post-injection, only one patient died due to pulmonary embolism. From the remaining 7 patients, all had a stable course after 4 months and 5 were stable for the first 8 months post-injection and deteriorated afterwards. Discussion In this study, intraspinal injection of bone marrow derived neural stem cells appears to be safe. Patients experienced a temporary stabilization for the first few months post-injection and then gradually deteriorated. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect