Patterns of Brain Injury in Perinatal Arterial Ischemic Stroke and the Development of Infantile Spasms
| Autor: | Ratika Srivastava, Edward A. Armstrong, Francois-Dominique Morneau-Jacob, Jerome Y. Yager, Oriana E. F. Shaw |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty 03 medical and health sciences Epilepsy 0302 clinical medicine Risk Factors 030225 pediatrics Internal medicine Perinatal stroke Humans Medicine cardiovascular diseases Ischemic Stroke Retrospective Studies Perinatal arterial ischemic stroke business.industry Infant Newborn Infant West Syndrome Prognosis medicine.disease Magnetic Resonance Imaging Brain Injuries Pediatrics Perinatology and Child Health Ischemic stroke Cardiology Female Neurology (clinical) business Spasms Infantile 030217 neurology & neurosurgery |
| Zdroj: | Journal of Child Neurology. 36:583-588 |
| ISSN: | 1708-8283 0883-0738 |
| DOI: | 10.1177/0883073820986056 |
| Popis: | Introduction:Perinatal arterial ischemic stroke (PAIS) underlies approximately 10% of infantile spasms (IS). We aim to identify patterns of brain injury in ischemic stroke that may predispose infants to infantile spasms.Methods:Sixty-four perinatal arterial ischemic stroke patients were identified meeting the following inclusion criteria: term birth, magnetic resonance imaging (MRI) showing ischemic stroke or encephalomalacia in an arterial distribution, and follow-up records. Patients who developed infantile spasms (PAIS-IS) were analyzed descriptively for ischemic stroke injury patterns and were compared to a seizure-free control group (PAIS-only). Stroke injury was scored using the modified pediatric ASPECTS (modASPECTS).Results:The PAIS-IS (n = 9) group had significantly higher modASPECTS than the PAIS-only (n = 16) group ( P = .002, Mann-Whitney). A greater proportion of PAIS-IS patients had injury to deep cerebral structures (67%) than PAIS-only (25%).Conclusion:Infarct size was significantly associated with infantile spasms development. Results support theories implicating deep cerebral structures in infantile spasms pathogenesis. This may help identify perinatal arterial ischemic stroke patients at risk of infantile spasms, facilitating more timely diagnosis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|