Changes in the sex hormone profile of male patients with moderate-to-severe plaque-type psoriasis under systemic therapy: results of a prospective longitudinal pilot study

Autor: Jurate Garbaraviciene, Sandra Boehncke, Falk Ochsendorf, Heike Beschmann, Wolf-Henning Boehncke, Rebekka Salgo, Hanns Ackermann
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Leptin
Adult
Male
Risk
medicine.medical_specialty
Psoriasis/*diagnosis/drug therapy/physiopathology
Context (language use)
Pilot Projects
Dermatology
Systemic inflammation
Insulin resistance
Sex hormone-binding globulin
Biological Markers/*metabolism
Sex Hormone-Binding Globulin/*metabolism
Psoriasis
Internal medicine
Sex Hormone-Binding Globulin
medicine
Humans
Resistin
Testosterone
Cardiovascular Diseases/*diagnosis/drug therapy/physiopathology
Prospective Studies
Prospective cohort study
Aged
Inflammation
biology
business.industry
C-Reactive Protein/metabolism
Leptin/metabolism
General Medicine
Middle Aged
medicine.disease
Testosterone/metabolism
Resistin/*metabolism
Endocrinology
C-Reactive Protein
Cardiovascular Diseases
Cohort
biology.protein
Disease Progression
medicine.symptom
Insulin Resistance
business
Biomarkers
Follow-Up Studies
Zdroj: Archives of Dermatological Research, Vol. 303, No 6 (2011) pp. 417-424
ISSN: 0340-3696
Popis: Patients with moderate-to-severe plaque-type psoriasis exhibit increased cardiovascular mortality. Recent publications point towards psoriasis-induced insulin resistance as an important pathomechanism driving cardiovascular comorbidity in these patients. As the hormonal status in general and sex hormone-binding globulin (SHBG) in particular serve as sensitive indicators for insulin resistance, we analysed these parameters in the context of a set of multiple additional clinical and laboratory measurements in a cohort of male patients. Of 33 consecutively enrolled male patients receiving continuous systemic therapy for their moderate-to-severe plaque-type psoriasis, 23 male patients for whom all parameters could be collected over a 24-week treatment period were included in this analysis. At baseline, testosterone levels varied between 212 and 660 ng/ml (median: 377.0), and SHBG between 11.9 and 46.0 nmol/l (median: 29.2), thus documenting lack of hypogonadism among these patients. Clinically, 19/23 patients experienced at least a 50% reduction in their PASI under therapy. Using a multivariate regression model to further analyse the sub-group of patients responding to treatment, hs-CRP, PASI, leptin and resistin all improved under effective systemic anti-inflammatory therapy, thus losing their significant influence on SHBG. SHBG performed well as a sensitive biomarker for insulin resistance and systemic inflammation in these patients. Its improvement, as well as the reduction of resistin serum levels, most likely reflects a state of reduced cardiovascular risk in patients undergoing effective continuous systemic therapy. Long-term safety data, generated e.g. from psoriasis registries, are needed to assess whether this effect translates into reduced cardiovascular mortality.
Databáze: OpenAIRE
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