Comparative effectiveness of neoadjuvant chemotherapy in bladder and upper urinary tract urothelial carcinoma
| Autor: | Surena F. Matin, Andrew C. Thorpe, Wassim Kassouf, Colin P.N. Dinney, Andrew J. Stephenson, Trinity J. Bivalacqua, Yair Lotan, Firas G. Petros, Marc A. Dall'Era, Homayoun Zargar, Todd M. Morgan, Peter C. Black, Jonathan L. Wright, Shahrokh F. Shariat, Philippe E. Spiess, Srikala S. Sridhar, John S. McGrath, Daniel A. Barocas, David D'Andrea, Michael S. Cookson, Jeffrey M. Holzbeierlein, Bas W.G. van Rhijn, Scott North, Siamak Daneshmand |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
#uroonc Urology 030232 urology & nephrology Logistic regression survival 03 medical and health sciences #blcsm 0302 clinical medicine medicine Stage (cooking) Radical surgery Bladder cancer response business.industry Proportional hazards model Hazard ratio #BladderCancer Odds ratio Original Articles medicine.disease upper tract urothelial carcinoma Confidence interval 030220 oncology & carcinogenesis #utuc bladder cancer Original Article business neoadjuvant chemotherapy |
| Zdroj: | Bju International |
| ISSN: | 1464-410X 1464-4096 |
| Popis: | OBJECTIVE To assess the differential response to neoadjuvant chemotherapy (NAC) in patients with urothelial carcinoma of the bladder (UCB) compared to upper tract urothelial carcioma (UTUC) treated with radical surgery. PATIENTS AND METHODS Data from 1299 patients with UCB and 276 with UTUC were obtained from multicentric collaborations. The association of disease location (UCB vs UTUC) with pathological complete response (pCR, defined as a post-treatment pathological stage ypT0N0) and pathological objective response (pOR, defined as ypT0-Ta-Tis-T1N0) after NAC was evaluated using logistic regression analyses. The association with overall (OS) and cancer-specific survival (CSS) was evaluated using Cox regression analyses. RESULTS A pCR was found in 250 (19.2%) patients with UCB and in 23 (8.3%) with UTUC (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text