Differential Effects of Recombinant Human Granulocyte Colony-Stimulating Factor (rhG-CSF) on the Radiation Sensitivity of Normal Versus Leukemic Bone Marrow Progenitor Cell Populations
| Autor: | Kevin G. Waddick, Mridula Chandan-Langlie, Fatih M. Uckun |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Cancer Research
Acute myeloblastic leukemia Cell Survival Radiation-Protective Agents Granulocyte Radiation sensitivity Bone Marrow hemic and lymphatic diseases Granulocyte Colony-Stimulating Factor Tumor Cells Cultured Humans Medicine Progenitor cell Cells Cultured Interleukin 3 Interleukin-6 business.industry fungi Hematology Precursor Cell Lymphoblastic Leukemia-Lymphoma Total body irradiation Hematopoietic Stem Cells medicine.disease Combined Modality Therapy Recombinant Proteins Granulocyte colony-stimulating factor Leukemia Myeloid Acute medicine.anatomical_structure Oncology Immunology Interleukin-3 lipids (amino acids peptides and proteins) Bone marrow business |
| Zdroj: | Leukemia & Lymphoma. 25:77-90 |
| ISSN: | 1029-2403 1042-8194 |
| Popis: | We examined the effects of recombinant human granulocyte colony-stimulating factor (rhG-CSF), interleukin 3 (rhIL-3) and interleukin 6 (rhIL-6) on the radiation sensitivity of normal and leukemic bone marrow progenitor cell populations. Conditioning of leukemic progenitor cells (LPC) from acute lymphoblastic leukemia (ALL) patients with rhG-CSF enhanced their radiation sensitivity, whereas conditioning with rhIL-3 or rhIL-6 had the opposite effect. In contrast to its effects on LPC derived from ALL patients, rhG-CSF reduced the radiation sensitivity of normal myeloid progenitor cells as well as LPC from acute myeloblastic leukemia (AML) patients. Differential modulation of the radiation sensitivity of LPC by rhG-CSF may provide the basis for better total body irradiation (TBI) regimens for ALL patients undergoing autologous bone marrow transplantation (BMT). |
| Databáze: | OpenAIRE |
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