Efficacy of Sirolimus-Eluting Stents Compared With Bare Metal Stents for Saphenous Vein Graft Intervention
Autor: | Ellen Pinnow, William W. Chu, Lowell F. Satler, Edouard Cheneau, Kenneth M. Kent, Joseph Lindsay, Jana Alexieva-Fournadjiev, Seung-Woon Rha, Rebecca Torguson, Pramod K. Kuchulakanti, Ron Waksman, Augusto D. Pichard |
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Rok vydání: | 2006 |
Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Saphenous vein graft Myocardial Infarction Electrocardiography Intervention (counseling) Internal medicine Myocardial Revascularization Creatine Kinase MB Form Humans Medicine Bare metal Saphenous Vein Angioplasty Balloon Coronary Aged Sirolimus business.industry Graft Occlusion Vascular Percutaneous coronary intervention Stent Surgery Circulatory system Cardiology Female Stents Cardiology and Cardiovascular Medicine business Immunosuppressive Agents Follow-Up Studies medicine.drug Angiographic restenosis |
Zdroj: | The American Journal of Cardiology. 97:34-37 |
ISSN: | 0002-9149 |
Popis: | Saphenous vein graft (SVG) intervention is associated with a significantly increased rate of periprocedural complications and late clinical and angiographic restenosis. We examined the efficacy and safety of sirolimus-eluting stents (SESs; Cypher) compared with bare metal stents (BMSs) in SVG intervention. Forty-eight patients who had 50 SVG lesions and underwent standard percutaneous coronary intervention with SESs (SES group) were compared with 57 patients who had 64 SVG lesions and underwent intervention with BMSs (BMS group). All patients received distal protection devices during SVG intervention. In-hospital, 30-day, 6-month, and 1-year clinical outcomes in the 2 groups were compared. Baseline clinical and procedural characteristics were balanced between groups. There were no deaths or Q-wave myocardial infarctions during the index hospitalization, but compared with the BMS group, patients in the SES group had significantly fewer non-Q-wave myocardial infarctions (4% vs 21%, p = 0.01), which was mainly attributed to increased periprocedural creatine kinase-MB levels. At 30-day, 6-month, and 1-year follow-ups, all clinical outcomes were similar between groups. Event-free survival at 1 year was also similar between groups (p = 0.84). In conclusion, the use of SESs in patients who undergo SVG intervention with a distal protection device is clinically safe and feasible but is not associated with decreased clinical events up to 1 year compared with BMSs. |
Databáze: | OpenAIRE |
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