Influence of the time interval from diagnosis to treatment on survival for early-stage liver cancer

Autor: Ya-Hsin Li, Yueh-Hsin Wang, Wei-Yin Kuo, Wen-Chen Tsai, Pei-Tseng Kung
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Male
Economics
Cancer Treatment
Social Sciences
lcsh:Medicine
Geographical Locations
0302 clinical medicine
Stage II Liver Cancer
Medicine and Health Sciences
Registries
030212 general & internal medicine
lcsh:Science
Multidisciplinary
Liver Diseases
Mortality rate
Liver Neoplasms
Hazard ratio
Middle Aged
Hospitals
Survival Rate
Oncology
030220 oncology & carcinogenesis
Female
Research Article
Adult
medicine.medical_specialty
Asia
Death Rates
Taiwan
Gastroenterology and Hepatology
Carcinomas
Time-to-Treatment
03 medical and health sciences
Health Economics
Population Metrics
Diagnostic Medicine
Internal medicine
Gastrointestinal Tumors
Cancer Detection and Diagnosis
medicine
Humans
Survival rate
Aged
Neoplasm Staging
Retrospective Studies
Cancer Death Rate
Population Biology
business.industry
lcsh:R
Cancers and Neoplasms
Biology and Life Sciences
Cancer
Retrospective cohort study
Hepatocellular Carcinoma
medicine.disease
Survival Analysis
Cancer registry
Health Care
Socioeconomic Factors
Health Care Facilities
People and Places
lcsh:Q
business
Health Insurance
Zdroj: PLoS ONE, Vol 13, Iss 6, p e0199532 (2018)
PLoS ONE
ISSN: 1932-6203
Popis: Objectives Liver cancer is the fifth most common cancer in men and the ninth most common cancer in women, and the WHO expects that there will be 1,341,344 cases in 2034 worldwide. Liver cancer also has the second-highest cancer death rate, accounting for 7% of all cancers. The study is going to explore the relationship between time interval from diagnosis to treatment and survival status of early-stage liver cancer patients. Materials and methods This is a retrospective cohort study using the national database from Taiwan. The datasets include the Taiwan Cancer Registry Database (TCR), the National Health Insurance Research Database (NHIRD), and the National Registry of Deaths. The target population for the study was patients newly diagnosed with stage I and stage II liver cancer between the years 2004 and 2010. Total of 26,038 cases were included in the study. Except descriptive analysis, the relationship between patient characteristics and the time interval from diagnosis to treatment was examined by chi-square tests. In addition, modified Cox proportional hazard models were used to analyze the hazard ratio of patient death with various treatment delay durations. Results There were 20,430 patients (78.46%) who received treatment less than 30 days after diagnosis, while 2,674 patients (10.27%) received treatment between 31 and 60 days after diagnosis, and 2,068 patients (7.94%) received treatment between 61 and 180 days after diagnosis, and 866 patients (3.33%) who received treatment 181 days after diagnosis. Those treated more than 181 days and 61–180 days after diagnosis had a 1.68-fold increased risk of death (95% confidence interval: 1.50–1.88) and a 1.39-fold increased risk of death (95% confidence interval: 1.31–1.17), respectively. Being male, being elderly, having a higher CCI level, and being treated in a hospital with a low service volume were factors associated with a poorer prognosis. Conclusion Overall, this study utilized a national cohort to conclude that for early-stage liver cancer patients, a longer the time interval from diagnosis to treatment results in a lower survival rate.
Databáze: OpenAIRE
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