High circulating levels of cytokines (IL-6 and TNFa), adhesion molecules (VCAM-1 and ICAM-1) and selectins in patients with peripheral arterial disease at rest and after a treadmill test
| Autor: | Daniele Digrandi, Vittorio Virgilio, Giuseppe Pennisi, Gabriella Celotta, Giuseppe Marchese, Salvatore Santo Signorelli, Maria Pia Costa, Carmela Porto, Grazia Malaponte, Luigi Di Pino, Maria Clorinda Mazzarino |
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| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty Arteriosclerosis Rest Vascular Cell Adhesion Molecule-1 Antineoplastic Agents Arterial Occlusive Diseases Inflammation 030204 cardiovascular system & hematology Systemic inflammation 03 medical and health sciences 0302 clinical medicine Internal medicine White blood cell E-selectin medicine Humans 030212 general & internal medicine Interleukin 6 Exercise Aged Peripheral Vascular Diseases biology Interleukin-6 Tumor Necrosis Factor-alpha business.industry Interleukin Middle Aged Intercellular Adhesion Molecule-1 Endocrinology medicine.anatomical_structure Immunology Exercise Test Selectins biology.protein Female Inflammation Mediators medicine.symptom Cardiology and Cardiovascular Medicine Claudication business Selectin |
| Zdroj: | Vascular Medicine. 8:15-19 |
| ISSN: | 1477-0377 1358-863X |
| Popis: | Peripheral arterial disease (PAD) is a common manifestation of atherosclerosis that is associated with systemic inflammation. The aim of our study was to assess whether plasma markers of inflammation increased after exercise in patients with PAD. The study was conducted on two groups of 20 subjects each: one group (mean age 68.4 6 5.09 years) was affected by PAD with claudication, while the other group consisted of healthy controls (66.9 6 6.1 years). Concentrations of interleukin 6 (IL-6) and tumor necrosis factor alpha (TNFa) were determined in plasma, in supernatants and in cells stimulated with 1 mg lipopolysaccharide in all patients. E-selectin (ES), L-selectin (LS) and P-selectin (PS) concentrations and plasma concentrations of VCAM-1 and ICAM-I were also determined. All determinations were performed in patients at rest and after the treadmill exercise. Resting values of soluble mediators were greater in PAD patients than in controls. They increased in both groups after the treadmill test, even if post-treadmill concentrations were signifi cantly higher in PAD patients (PAD p < 0.001 or 0.0001, controls p < 0.05 or 0.001). These results confi rm that white blood cell activation is characteristic of systemic atherosclerosis and that these inflammation markers increase in conditions of hemodynamic stress. |
| Databáze: | OpenAIRE |
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