Daily iTBS worsens hand motor training--a combined TMS, fMRI and mirror training study
| Autor: | Farsin Hamzei, C. H. Läppchen, Rüdiger Lange, J. Blessin, K Schulz, T. Ringer, Gundula Seidel |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Motor training Cognitive Neuroscience medicine.medical_treatment Stimulation Functional Laterality Premotor cortex Random Allocation Young Adult Physical medicine and rehabilitation Neuroplasticity medicine Humans Learning Theta Rhythm Stroke Mirror Neurons Neuronal Plasticity Supplementary motor area Motor Cortex Training effect medicine.disease Magnetic Resonance Imaging Transcranial Magnetic Stimulation Transcranial magnetic stimulation medicine.anatomical_structure Neurology Motor Skills Female Psychology Neuroscience Psychomotor Performance |
| Zdroj: | NeuroImage. 107 |
| ISSN: | 1095-9572 |
| Popis: | Introduction Repetitive transcranial magnetic stimulation (rTMS) is used to increase regional excitability to improve motor function in combination with training after neurological diseases or events such as stroke. We investigated whether a daily application of intermittent theta burst stimulation (iTBS; a short-duration rTMS that increases regional excitability) improves the training effect compared with sham stimulation in association with a four-day hand training program using a mirror (mirror training, MT). The right dorsal premotor cortex (dPMCright) was chosen as the target region for iTBS because this region has recently been emphasized as a node within a network related to MT. Methods Healthy subjects were randomized into the iTBS group or sham group (control group CG). In the iTBS group, iTBS was applied daily over dPMCright, which was functionally determined in an initial fMRI session prior to starting MT. MT involved 20 min of hand training daily in a mirror over four days. The hand tests, the intracortical excitability and fMRI were evaluated prior to and at the end of MT. Results The results of the hand training tests of the iTBS group were surprisingly significantly poorer compared with those from the CG group. Both groups showed a different course of excitability in both M1 and a different course of fMRI activation within the supplementary motor area and M1left. Conclusion We suggest the inter-regional functional balance was affected by daily iTBS over dPMCright. Maybe an inter-regional connectivity within a network is differentially balanced. An excitability increase within an inhibitory-balanced network would therefore disturb the underlying network. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect