Cytokine gene polymorphism and early graft rejection in liver transplant recipients
| Autor: | Yaman Tokat, H.O Ayanoglu, B. Basturk, Mahir Akyildiz, Zeki Karasu, Sezgin Ulukaya, Engin Ulukaya |
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| Přispěvatelé: | Uludağ Üniversitesi/Tıp Fakültesi/İmmunoloji Anabilim Dalı., Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyokimya Anabilim Dalı., Baştürk, Bilkay, Ulukaya, Engin, AAD-6918-2021, K-5792-2018 |
| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: |
Male
Interleukin-10 gene medicine.medical_treatment Protein function Interleukin 6 Liver transplantation Promoter polymorphisms Kidney Heart-transplantation Interleukin 10 Genotype Interferon gamma Middle aged DNA extraction Priority journal Gene expression regulation Cyclosporin Interleukin Kidney Transplantation Genetic Polymorphism Graft Rejection Correlation analysis Polymerase chain reaction Necrosis-factor-alpha Cytokine Phenotype Graft rejection Cytokines Female Liver graft rejection medicine.drug TNF-alpha Human Adult Adolescent Clinical article Immunology Genotypes Polymorphism genetic Methylprednisolone Tacrolimus Article Renal-allograft rejection Association Interferon-gamma medicine Humans Allele Steroid Gamma interferon Liver graft Transplantation business.industry Tumor necrosis factor alpha Base sequence Gene frequency Genotype frequency DNA polymorphism Surgery Transforming growth factor beta business Controlled study |
| Popis: | Cytokines, which play important roles in allograft rejection, show variable production among individuals. These variations may be related to genetic polymorphisms within the regulatory regions of the cytokine genes. We investigated the association between the role tumor necrosis factor alpha (TNF-alpha), transforming growth factor-beta (TGF-beta), interferon gamma (IFN-gamma), interleukin (IL)-10 and IL-6 gene polymorphisms and early graft rejection among liver transplant recipients. Forty-three liver transplant recipients enrolled in this study were divided into 2 groups based on events in the first 2 months posttransplantations, namely, those experiencing at least 1 rejection episode (n = 26) or those without any episode (n = 17). The allele or genotype frequencies of cytokine gene polymorphisms showed no difference between liver recipients with or without nonrejection. In conclusion, there was no significant correlation between early graft rejection and cytokine gene polymorphism of TNF-alpha, TGF-beta, IL-10, IL-6, and IFN-gamma in liver transplant recipients. |
| Databáze: | OpenAIRE |
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