Intra-articular mepivacaine reduces interventional analgesia requirements during arthroscopic surgery in dogs
| Autor: | M. A. Gurney, T. A. G. Dutton, S. R. Bright |
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| Rok vydání: | 2014 |
| Předmět: |
musculoskeletal diseases
Male Mean arterial pressure medicine.medical_specialty Haemodynamic response medicine.medical_treatment Mepivacaine Fentanyl Injections Intra-Articular Arthroscopy Dogs medicine Animals Anesthetics Local Small Animals Saline medicine.diagnostic_test business.industry Hemodynamics Arthrocentesis Cannula Surgery Anesthesia Female Analgesia Joint Diseases business medicine.drug |
| Zdroj: | The Journal of small animal practice. 55(8) |
| ISSN: | 1748-5827 |
| Popis: | Objectives To document efficacy of intra-articular mepivacaine in dogs based on the hypothesis that this would blunt the haemodynamic response to a nociceptive stimulus (arthroscopic surgery), reducing interventional analgesia requirements. Methods A dose of mepivacaine 2% 0 · 1 ml/kg (2 mg/kg) was injected intra-articularly into one randomly assigned elbow joint before surgery in eight dogs undergoing bilateral elbow arthroscopy. Baseline haemodynamic measurements were recorded immediately before the start of each arthroscopic procedure and repeated at arthrocentesis, saline distension of the joint, incision, arthroscopic cannula and obturator insertion and placement of the second portal and haemodynamic variability calculated. If baseline parameters increased by more than 20% suggesting nociception, 1 µg/kg fentanyl was administered intravenously. Results Significantly less fentanyl was required during arthroscopy on the mepivacaine treated elbows compared to the non-treated elbows (P = 0 · 003) and the time to first fentanyl administration was significantly longer (P = 0 · 0001) in the mepivacaine treated elbows (21 · 2 ± 4 · 9 minutes) compared to the non-treated elbows (6 · 1 ± 2 · 3 minutes). Haemodynamic variability was significantly reduced in the mepivacaine group (heart rate P = 0 · 04, mean arterial pressure P = 0 · 003). Clinical Significance Intra-articular mepivacaine blunts the haemodynamic response to arthroscopic surgery in dogs and reduces interventional analgesia requirement. |
| Databáze: | OpenAIRE |
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