Association of GOLPH2 expression with survival in non-small-cell lung cancer: clinical implications and biological validation
| Autor: | Biao Han, Yu Zhang, Wenteng Hu, Ruijiang Lin, Liwei Wang, Ning Wei |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine Oncology medicine.medical_specialty Lung Neoplasms Clinical Biochemistry Independent predictor Nsclc tissue 03 medical and health sciences 0302 clinical medicine Cancer Survivors Carcinoma Non-Small-Cell Lung Internal medicine Drug Discovery Biomarkers Tumor medicine Biological validation Humans Lung cancer neoplasms Pathological Aged Gene knockdown business.industry Biochemistry (medical) Membrane Proteins Middle Aged medicine.disease Neoplasm Proteins respiratory tract diseases Gene Expression Regulation Neoplastic 030104 developmental biology Normal lung 030220 oncology & carcinogenesis Female Non small cell business |
| Zdroj: | Biomarkers in Medicine. 11:967-977 |
| ISSN: | 1752-0371 1752-0363 |
| Popis: | Aim: We investigated the role of GOLPH2 in non-small-cell lung cancer (NSCLC). Methods: We analyzed the relationship between the expression of GOLPH2 and the clinical pathological characteristics of patients with NSCLC. The function of GOLPH2 in NSCLC cell lines was also explored through overexpression and knockdown studies. Results: The positive expression rate of GOLPH2 protein in NSCLC tissue was higher than that of normal lung tissue. We found that positive GOLPH2 expression was closely associated with unfavorable features of patients with NSCLC. The GOLPH2 expression was an independent predictor of the prognosis of patients with NSCLC. That GOLPH2 can promote the proliferation and invasion of NSCLC cells. Conclusion: The GOLPH2 is a novel marker for NSCLC. |
| Databáze: | OpenAIRE |
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