Effects of Fumonisin B1 in Pregnant Rats
| Autor: | Deborah K. Hansen, James B. LaBorde, Nicholas Olejnik, Thomas F.X. Collins, M.A. Bryant, Dennis I. Ruggles, Robert M. Eppley, J.I. Rorie, Paul C. Howard, M.W. Trucksess, Robert L. Sprando, M.E. Shackelford, T.N. Black |
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| Rok vydání: | 1998 |
| Předmět: |
Male
medicine.medical_specialty Carboxylic Acids Drinking Physiology Biology Kidney Toxicology Fumonisins Eating Embryonic and Fetal Development chemistry.chemical_compound Pregnancy Sphingosine Oral administration Internal medicine Fumonisin medicine Animals Mycotoxin Fumonisin B1 Fetus Reproduction Body Weight Abnormalities Drug-Induced Brain Organ Size General Medicine medicine.disease Rats Teratogens Endocrinology Liver chemistry Toxicity Gestation Female Food Science |
| Zdroj: | Food and Chemical Toxicology. 36:397-408 |
| ISSN: | 0278-6915 |
| DOI: | 10.1016/s0278-6915(97)00170-1 |
| Popis: | Fumonisin B1 (FB1), the major mycotoxin from Fusarium moniliforme, has been implicated as a causative agent in several animal and human diseases. Despite animal toxicity studies and human epidemiological studies of FB1, knowledge of its reproductive effects is scarce. In this study, one of a series of proposed studies that will allow extrapolation to humans, pregnant rats were given oral doses of 0, 1.875, 3.75, 7.5 or 15 mg FB1/kg on gestation days 3–16. Caesarean sections were performed on day 17 or 20, and maternal condition, implantation efficiency, foetal viability and foetal development were measured. Dose-related decreases in overall feed consumption and body weight gain were seen, but only the feed consumption decrease at 15 mg/kg, and the decreased body weight gain at 15 mg/kg on days 0–17 were statistically significant. Foetal body weights at day 17 were similar in control and treated groups; but in day-20 foetuses, female weight and crown–rump length were significantly decreased at 15 mg/kg. FB1 was not teratogenic at the doses tested, and no dose-related effects were seen in either skeletal or soft-tissue development. In day-17 animals, maternal and foetal brain, liver and kidney tissues, and maternal serum were preserved to study the levels of sphinganine (Sa), sphingosine (So), and the Sa/So ratios. Dose-related increases were seen in Sa/So ratios in maternal livers, kidneys and serum. Sa/So ratios of maternal brains were not affected, nor were those of foetal kidneys, livers or brains. |
| Databáze: | OpenAIRE |
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