Stem cell topography splits growth and homeostatic functions in the fish gill
Autor: | Kiyoshi Naruse, Elizabeth Mayela Ambrosio, Anna Marciniak-Czochra, Diana-Patricia Danciu, Lorena Buono, Juan Ramón Martínez-Morales, Julian Stolper, Lazaro Centanin, David A. Elliott |
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Přispěvatelé: | German Research Foundation, Fundación Ramón Areces, University of Melbourne |
Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
Gills endocrine system animal structures fate-restriction QH301-705.5 Science Niche Oryzias Biology adult stem cells Regenerative medicine General Biochemistry Genetics and Molecular Biology organ growth 03 medical and health sciences 0302 clinical medicine Animals Homeostasis Humans Biology (General) Stem Cell Niche medaka General Immunology and Microbiology Chimera General Neuroscience hemic and immune systems Cell Differentiation General Medicine Genes p53 Stem Cells and Regenerative Medicine eye diseases Cell biology 030104 developmental biology Adipose Tissue Medicine Other Stem cell Developmental biology lineage analysis 030217 neurology & neurosurgery Function (biology) Fish gill Adult stem cell Research Article Developmental Biology growth coordination |
Zdroj: | eLife eLife, Vol 8 (2019) Digital.CSIC. Repositorio Institucional del CSIC instname |
ISSN: | 2050-084X |
Popis: | While lower vertebrates contain adult stem cells (aSCs) that maintain homeostasis and drive un-exhaustive organismal growth, mammalian aSCs display mainly the homeostatic function. Here, we use lineage analysis in the medaka fish gill to address aSCs and report separate stem cell populations for homeostasis and growth. These aSCs are fate-restricted during the entire post-embryonic life and even during re-generation paradigms. We use chimeric animals to demonstrate that p53 mediates growth coordination among fate-restricted aSCs, suggesting a hierarchical organisation among lineages in composite organs like the fish gill. Homeostatic and growth aSCs are clonal but differ in their topology; modifications in tissue architecture can convert the homeostatic zone into a growth zone, indicating a leading role for the physical niche defining stem cell output. We hypothesise that physical niches are main players to restrict aSCs to a homeostatic function in animals with fixed adult size. This work has been funded by the Deutsche Forschungsgemeinschaft (German Research Foundation, DFG) via the Collaborative Research Centre SFB873 (subproject A11 to LC and B08 to AMC). LB gratefully acknowledges Ramon Areces Foundation’s support, D-PD the Research Training Group (Landesgraduiertenkolleg) “Mathematical Modeling for the Quantitative Biosciences” and Heidelberg Graduate School (HGS MathComp) and LC acknowledges support from the DAAD. JS is the recipient of a Melbourne Research Scholarship from the University of Melbourne, Australia. |
Databáze: | OpenAIRE |
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