Effect of voluntary exercise upon the metabolic syndrome and gut microbiome composition in mice
| Autor: | Simon T. Hui, Christina Q. Nguyen, Linsey Stiles, Alexander R. Strumwasser, Timothy M. Moore, Lorraine P. Turcotte, Akshay T. S. Anand, Frode Norheim, Xiaopeng Zhu, Jennifer M. Lang, Amanda J. Lin, Anthony Terrazas, Zhenqi Zhou |
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| Rok vydání: | 2021 |
| Předmět: |
Male
obesity Physiology Medical Physiology microbiome Mitochondria Liver Inbred C57BL Cardiovascular Oral and gastrointestinal Running Mice Receptors 2.1 Biological and endogenous factors QP1-981 Medicine Aetiology Adiposity Metabolic Syndrome exercise Liver Disease Physical Conditioning Mitochondria medicine.anatomical_structure Liver Knockout mouse Original Article Clinical Sciences metabolic syndrome LDL Rare Diseases Endurance training Physical Conditioning Animal Physiology (medical) Animals Microbiome Metabolic and endocrine Nutrition Animal business.industry Prevention Skeletal muscle Original Articles medicine.disease Obesity Gastrointestinal Microbiome Mice Inbred C57BL Glucose LDLR Receptors LDL LDL receptor Metabolic syndrome Digestive Diseases business Lipoprotein |
| Zdroj: | Physiological Reports Physiological Reports, Vol 9, Iss 21, Pp n/a-n/a (2021) Physiological reports, vol 9, iss 21 |
| ISSN: | 2051-817X |
| DOI: | 10.14814/phy2.15068 |
| Popis: | The metabolic syndrome is a cluster of conditions that increase an individual's risk of developing diseases. Being physically active throughout life is known to reduce the prevalence and onset of some aspects of the metabolic syndrome. Furthermore, previous studies have demonstrated that an individual's gut microbiome composition has a large influence on several aspects of the metabolic syndrome. However, the mechanism(s) by which physical activity may improve metabolic health are not well understood. We sought to determine if endurance exercise is sufficient to prevent or ameliorate the development of the metabolic syndrome and its associated diseases. We also analyzed the impact of physical activity under metabolic syndrome progression upon the gut microbiome composition. Utilizing whole‐body low‐density lipoprotein receptor (LDLR) knockout mice on a “Western Diet,” we show that long‐term exercise acts favorably upon glucose tolerance, adiposity, and liver lipids. Exercise increased mitochondrial abundance in skeletal muscle but did not reduce liver fibrosis, aortic lesion area, or plasma lipids. Lastly, we observed several changes in gut bacteria and their novel associations with metabolic parameters of clinical importance. Altogether, our results indicate that exercise can ameliorate some aspects of the metabolic syndrome progression and alter the gut microbiome composition. In this study, we sought to determine if endurance exercise is sufficient to prevent or ameliorate the development of metabolic syndrome and its associated diseases and the impact of physical activity under metabolic syndrome progression upon the gut microbiome. Utilizing the whole‐body low‐density lipoprotein receptor (LDLR) knockout mice on a “Western Diet,” we show that long‐term exercise acts favorably upon glucose tolerance, adiposity, and liver lipids. Our results indicate that exercise can ameliorate some aspects of the metabolic syndrome progression and alter the gut microbiome. |
| Databáze: | OpenAIRE |
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