BDNF and COMT, but not APOE, Alleles are Associated with Psychiatric Symptoms in Refractory Epilepsy
| Autor: | Imad Najm, Olivia Hogue, Charis Eng, Jessica Altemus, Christine Doherty, Darlene Floden, Robyn M. Busch |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Drug Resistant Epilepsy Genotype Catechol O-Methyltransferase Article 03 medical and health sciences Behavioral Neuroscience Epilepsy 0302 clinical medicine Apolipoproteins E medicine Humans 030212 general & internal medicine Psychiatry Alleles Retrospective Studies business.industry Brain-Derived Neurotrophic Factor Mental Disorders Middle Aged medicine.disease Mood Cross-Sectional Studies Neurology Schizophrenia Anxiety Female Neurology (clinical) medicine.symptom Personality Assessment Inventory business rs6265 030217 neurology & neurosurgery Psychopathology rs4680 |
| Zdroj: | Epilepsy Behav |
| Popis: | Objective The objective of this study was to determine whether three common genetic polymorphisms [apolipoprotein (APOE) e4 (rs42938 and rs7412), brain derived neurotrophic factor (BDNF) Met (rs6265), and catechol-O-methyltransferase (COMT) Val (rs4680)] are associated with increased psychiatric symptomatology in individuals with pharmacoresistant epilepsy. Methods One hundred forty-eight adults (Mage = 38 years; 53% female) with refractory epilepsy completed self-report measures of mood, anxiety, and/or personality/psychopathology. Mann–Whitney U, t-tests, and Fisher's exact tests were used to determine if APOE4, BDNF Val66Met, or COMT Val158Met are associated with increased psychiatric symptomatology in people with epilepsy. Results As a group, BDNF Met carriers reported greater symptoms of depression on the Personality Assessment Inventory (PAI) than those without a Met allele (p = 0.004); COMT Val carriers reported greater symptoms on the PAI Schizophrenia (p = 0.007), Antisocial Features (p = 0.04), and Alcohol Problems (p = 0.03) scales than noncarriers. On the individual level, a significantly greater proportion of BDNF Met carriers demonstrated elevated PAI Depression scores compared to those without a Met allele (p = 0.046). There was also a larger proportion of COMT Val carriers with elevated PAI Anxiety scores as compared to those without a Val allele (p = 0.036). Significance This retrospective cross-sectional study provides preliminary evidence for a genetic basis of psychiatric comorbidities in epilepsy and suggests that BDNF and COMT may play an important role in the pathophysiology of mental health problems in this vulnerable population. |
| Databáze: | OpenAIRE |
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