Positive Association Between Serum Levels of High-Sensitivity C-Reactive Protein and Depression/Anxiety in Female, but Not Male, Patients With Type 2 Diabetes Mellitus
| Autor: | Fenglin Cao, Qian-Qian Yang, Min-Hua Fan, Di Shao, Chun-Ling Yang, Jie Li |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male China medicine.medical_specialty Inflammation Type 2 diabetes 03 medical and health sciences Sex Factors 0302 clinical medicine Risk Factors Internal medicine Prevalence Humans Medicine Depression (differential diagnoses) Aged Aged 80 and over Depressive Disorder Research and Theory biology business.industry C-reactive protein Type 2 Diabetes Mellitus Middle Aged medicine.disease Anxiety Disorders 030227 psychiatry C-Reactive Protein Cross-Sectional Studies Increased risk Diabetes Mellitus Type 2 Male patient biology.protein Anxiety Female medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Biological Research For Nursing. 22:178-187 |
| ISSN: | 1552-4175 1099-8004 |
| Popis: | Purpose: Patients with Type 2 diabetes (T2D) have increased risk of depression and anxiety. Evidence suggests that a heightened inflammatory state may contribute to this association. Females experience more depression and higher inflammation levels than males. This study compared associations of serum high-sensitivity C-reactive protein (hs-CRP) levels with symptoms of depression and anxiety between men and women with Type 2 diabetes mellitus (T2DM). Method: Cross-sectional data including demographic and disease characteristics, symptoms of depression and anxiety, clinical data, and laboratory values were collected from 392 patients with T2DM recruited from a general hospital in Shandong Province, China. We evaluated associations between serum hs-CRP level and symptoms of depression and anxiety in males and females separately using multiple linear regressions and χ2 tests for trend. Results: Sex moderated the association between serum hs-CRP level and symptoms of depression ( B = .112 [ SE = 0.049]; p = .022) and anxiety ( B = .137 [ SE = 0.053]; p = .011). Among females, hs-CRP level was positively associated with depression ( B = .034, 95% confidence interval [CI] = [.006, .061]; p = .016, false discovery rate [FDR]-adjusted p = .020) and anxiety ( B = .041, 95% CI [.011, .071], p = .007, FDR-adjusted p = .007). Positive trends indicated a higher prevalence of clinically significant symptoms of depression and anxiety in higher serum hs-CRP categories in females. No associations were found in males. Conclusion: Findings demonstrate that associations between serum hs-CRP level and symptoms of depression and anxiety in patients with T2D are sex-specific, with only females demonstrating a significant positive association. |
| Databáze: | OpenAIRE |
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