The Relationship between Maternal Gestational Impaired Glucose Tolerance and Risk of Large-for-Gestational-Age Infant: A Meta-Analysis of 14 Studies
| Autor: | Hai Qing Wang, Li Li, Yi Li, Han Lin Lai, Qi Fei Liu, Shuang Hu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Gestational Age large for gestational age Cochrane Library Risk Assessment Impaired glucose tolerance Cohort Studies 03 medical and health sciences Gestational impaired glucose tolerance 0302 clinical medicine Endocrinology Pregnancy Risk Factors Glucose Intolerance medicine Odds Ratio Birth Weight Humans 030212 general & internal medicine Rank correlation Obstetrics business.industry Case-control study Infant Newborn Gestational age Odds ratio Publication bias Overweight medicine.disease meta-analysis Diabetes Gestational Meta-analysis Case-Control Studies Pediatrics Perinatology and Child Health Original Article Female business |
| Zdroj: | Journal of Clinical Research in Pediatric Endocrinology |
| ISSN: | 1308-5735 1308-5727 |
| Popis: | Objective To explore, by conducting a meta-analysis, whether gestational impaired glucose tolerance (IGT) is an independent predictor of neonatal large for gestational age (LGA) or not. Methods Medline, Embase, and Cochrane Library databases were searched to identify published epidemiological studies (cohort and case-control studies) investigating the association between gestational IGT and neonatal LGA. Calculations of pooled estimates were conducted in random-effect models or fixed-effects models. Heterogeneity was tested by using chi-square test and I2 statistics. Egger's test (linear regression method) and Begg's test (rank correlation method) were used to assess potential publication bias. Results Fourteen observational studies were included in the meta-analysis. The overall risk for the effect of IGT on LGA was 2.09 (1.56, 2.78). Stratified analyses showed no differences regarding different geographic regions or the analysis of overall adjusted odds ratios. No evidence of publication bias was observed in either Egger's test or Begg's test results. Conclusion Gestational IGT is an independent predictor of neonatal LGA. |
| Databáze: | OpenAIRE |
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