Antioxidant and antiviral activity of common polyphenols against influenza A virus

Autor: Tran Van Cuong, Nguyen Thi Thoa
Rok vydání: 2022
Předmět:
DOI: 10.5281/zenodo.6962040
Popis: In this study, we compared the antioxidant activity, cytotoxicity, and antiviral activity of ten common phenolic acids and flavonoids which naturally occurred in many plants and byproducts sources. Antioxidant activity was analyzed using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2′-azinobis (3 ethylbenzothiazoline-6-sulfonic acids) (ABTS) radical-scavenging activity, while cytotoxicity and antiviral effects of the polyphenols were evaluated using MDCK cells line model. The results showed that different phenolic acids and flavonoids showed a significant difference in antioxidant activities as well as cytotoxicity. Amongst tested compounds, pyrogallol and catechin showed higher DPPH radical scavenging ability, while ellagic acid and quercetin had the higher ability for ABTS assay. Furthermore, our results indicated that the antiviral activity potential varied significantly among polyphenols, and that several compounds including gallic acid, quercetin, rutin and vanillic acid have potent antiviral activity against the influenza A virus.
{"references":["Celep, E., Aydin, A. and Yesilada, E. (2012). 'A comparative study on the in vitro antioxidant potentials of three edible fruits: Cornelian cherry, Japanese persimmon and cherry laurel', Food and Chemical Toxicology. Elsevier Ltd, 50(9), pp. 3329–3335. doi: 10.1016/j.fct.2012.06.010.","DIng, Y. et al. (2017). 'Antiviral activity of chlorogenic acid against influenza A (H1N1/H3N2) virus and its inhibition of neuraminidase', Scientific Reports. Nature Publishing Group, 7(March), pp. 1–11. doi: 10.1038/srep45723.","Friedman, M. (2007) 'Overview of antibacterial, antitoxin, antiviral, and antifungal activities of tea flavonoids and teas', Molecular Nutrition and Food Research. doi: 10.1002/mnfr.200600173.","Gaikwad, K. K., Singh, S. and Lee, Y. S. (2017) 'A new pyrogallol coated oxygen scavenging film and their effect on oxidative stability of soybean oil under different storage conditions', Food Science and Biotechnology, 26(6), pp. 1535–1543. doi: 10.1007/s10068-017-0232-x.","He, W. et al. (2011) 'Anti-influenza virus effect of aqueous extracts from dandelion', Virology Journal. BioMed Central Ltd, 8(1), p. 538. doi: 10.1186/1743-422X-8-538.","Huang, S.-J., Tsai, S.-Y. and Mau, J.-L. (2006) 'Antioxidant properties of methanolic extracts from Agrocybe cylindracea', LWT - Food Science and Technology, 39(4), pp. 379–387. doi: 10.1016/j.lwt.2005.02.012.","Ju, H. et al. (2017) 'Inhibitors of Influenza Virus Polymerase Acidic (PA) Endonuclease: Contemporary Developments and Perspectives', Journal of Medicinal Chemistry, 60(9), pp. 3533–3551. doi: 10.1021/acs.jmedchem.6b01227.","Lee, J.-H. et al. (2016) 'Antiviral Effects of Black Raspberry (Rubus coreanus) Seed and Its Gallic Acid against Influenza Virus Infection', Viruses, 8(6), p. 157. doi: 10.3390/v8060157.","Lin, D. et al. (2016) 'An overview of plant phenolic compounds and their importance in human nutrition and management of type 2 diabetes', Molecules, 21(10), p. 19. doi: 10.3390/molecules21101374.","Re, R. et al. (1999) 'Antioxidant activity applying an improved ABTS radical cation decolorization assay', Free Radical Biology and Medicine, 26(9–10), pp. 1231–1237. doi: 10.1016/S0891-5849(98)00315-3."]}
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