Improving the encapsulation efficiency and sustained release behaviour of chitosan/β-lactoglobulin double-coated microparticles by palmitic acid grafting
| Autor: | Jaehyeog Choe, Han-Joo Yang, Sanghoon Ko, Pei Sia Lee, Seokjin Suh |
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| Rok vydání: | 2016 |
| Předmět: |
Chemical Phenomena
Palmitic Acid 02 engineering and technology Lactoglobulins Analytical Chemistry Palmitic acid Chitosan Hydrophobic effect chemistry.chemical_compound 0404 agricultural biotechnology Microscopy Electron Transmission Spectroscopy Fourier Transform Infrared Organic chemistry Microparticle Particle Size Gastrointestinal fluids 04 agricultural and veterinary sciences General Medicine 021001 nanoscience & nanotechnology 040401 food science Hydrophobe Gastrointestinal Tract chemistry Delayed-Action Preparations Particle size 0210 nano-technology Hydrophobic and Hydrophilic Interactions Food Science Nuclear chemistry |
| Zdroj: | Food chemistry. 220 |
| ISSN: | 1873-7072 |
| Popis: | Chitosan (CS) was grafted with 0.1 and 0.5% (w/v) palmitic acid (PA) to improve its encapsulation efficiency (EE) and sustained release characteristics when forming CS microparticles. Thereafter, PA-grafted CS (PA-CS) microparticles were coated with denatured β-lactoglobulin (βlg), which forms an outer protective layer. The possibility of hydrophobic interaction with the hydrophobic substances in the CS microparticles increased as the proportion of the grafted PA increased. EE was measured as 64.79, 83.72, and 85.00% for the non-grafted, 0.1, and 0.5% PA-CS microparticles, respectively. In simulated small intestinal conditions, 4.66 and 17.55% of the core material release in the PA-CS microparticles were sustained after 180min by 0.1, and 0.5% PA grafting, respectively. PA grafting enables the sustained release in simulated gastrointestinal fluids by enhancing the hydrophobic interaction between CS and the hydrophobic core material. |
| Databáze: | OpenAIRE |
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