Inhibition of biofilm maturation by linezolid in meticillin-resistant Staphylococcus epidermidis clinical isolates: comparison with other drugs
| Autor: | Bárbara Villa, Pedro Alves d'Azevedo, Caio Fernando de Oliveira, Keli Cristine Reiter, Thiago Galvão da Silva Paim |
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| Rok vydání: | 2013 |
| Předmět: |
Microbiology (medical)
Prosthesis-Related Infections Bacteremia Microbial Sensitivity Tests Tigecycline Microbiology Methicillin chemistry.chemical_compound Bacterial Proteins Staphylococcus epidermidis Acetamides medicine Oxazolidinones Bacteriological Techniques Dose-Response Relationship Drug biology Linezolid Biofilm Gene Expression Regulation Bacterial General Medicine Staphylococcal Infections biochemical phenomena metabolism and nutrition bacterial infections and mycoses Antimicrobial biology.organism_classification Anti-Bacterial Agents chemistry Biofilms Vancomycin Methicillin Resistance Gentamicin Rifampicin medicine.drug |
| Zdroj: | Journal of Medical Microbiology. 62:394-399 |
| ISSN: | 1473-5644 0022-2615 |
| DOI: | 10.1099/jmm.0.048678-0 |
| Popis: | Biofilm resistance mechanisms are multifactorial and vary from one organism to another. The purpose of this study was to investigate the efficacy of linezolid against indwelling device-related meticillin-resistant Staphylococcus epidermidis (MRSE) biofilm, and compare this with other antimicrobials. MICs, minimum biofilm inhibitory concentrations (MBICs) and minimum biofilm eradication concentrations (MBECs) were determined by the microtitre plate method. Fourteen and thirteen isolates from patients with indwelling device-related bacteraemia (IDB) and indwelling device colonization not associated with bacteraemia, respectively, were assessed. High MBIC was associated with a high intensity of biofilm formation (gentamicin r = 0.796; linezolid r = 0.477; rifampicin r = 0.634; tigecycline r = 0.410; and vancomycin r = 0.771), but this correlation was not observed with MBEC. Linezolid demonstrated better in vitro antimicrobial activity than other antimicrobials (MBIC – gentamicin P |
| Databáze: | OpenAIRE |
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