Oxidative stress and apoptosis in heart dysfunction
| Autor: | Dinender Kumar, Huiquan Lou, Pawan K. Singal |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
medicine.medical_specialty
Programmed cell death Time Factors Heart disease Heart Diseases Cell Survival Cardiomyopathy Myocardial Infarction Antineoplastic Agents Apoptosis Disease DNA Fragmentation medicine.disease_cause Antioxidants Pathogenesis Necrosis Internal medicine medicine Animals Humans Myocytes Cardiac Myocardial infarction Cells Cultured Heart Failure Cell Death business.industry Myocardium medicine.disease Rats Oxidative Stress Doxorubicin Heart failure Reperfusion Injury Cardiology Rabbits Mitogen-Activated Protein Kinases Cardiology and Cardiovascular Medicine business Cardiomyopathies Reactive Oxygen Species Oxidative stress |
| Zdroj: | Herz. 27(7) |
| ISSN: | 0340-9937 |
| Popis: | Heart disease is a major cause of morbidity and mortality due to its complex pathogenesis. Myocyte cell loss through apoptosis has been reported in a variety of cardiovascular disease conditions including myocardial infarction (MI), ischemia-reperfusion injury, end-stage heart failure and adriamycin cardiomyopathy.The cell biology of the apoptotic regulatory processes and the precise role of apoptosis in the development of cardiac dysfunction need to be established. The upregulation of proapoptic proteins, like Bax (a member of the Bcl-2 family proteins), caspases and cytochrome c, with or without the downregulation of antiapoptic proteins, including Bcl-2 (another member of the Bcl family), Akt and inhibitory apoptotic proteins (IAPs), has been documented in different cardiac disease conditions. However, mitogen-activated protein kinases (MAPKs) have been shown to be involved in both apoptosis and cell survival. Apoptosis can be blocked by inhibiting apoptotic regulatory pathways with caspase inhibitors and overexpression of Bcl-2 and Akt. More recently, increased oxidative stress has been shown to promote apoptosis, and antioxidants have been shown to inhibit this process.The ability of antioxidants to inhibit these apoptotic pathways has raised the possibility of newer therapeutic treatment for various heart diseases. |
| Databáze: | OpenAIRE |
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