Selective excitation of myelin water using inversion-recovery-based preparations
| Autor: | Mark D. Does, Adam R. Travis |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Relaxometry
Chemistry Myelin water Analytical chemistry Inversion recovery Selective excitation In Vitro Techniques Magnetic Resonance Imaging Sciatic Nerve Magnetization Xenopus laevis Nuclear magnetic resonance Body Water T2 relaxation Frog sciatic nerve Animals Radiology Nuclear Medicine and imaging Selectivity Artifacts Myelin Sheath |
| Zdroj: | Magnetic resonance in medicine. 54(3) |
| ISSN: | 0740-3194 |
| Popis: | T1 and T2 relaxation of excised frog sciatic nerve water was characterized at 7 T. Based on these findings, optimal timings for multiple inversion-recovery magnetization preparations were determined to selectively excite the so-called myelin-water T2 component. Subsequent double inversion-recovery and triple inversion-recovery preparations were used in combination with CPMG acquisitions to experimentally determine optimal timings and effect of the preparation. Using double inversion-recovery, optimal timings were found to excite magnetization that is predominantly (approximately 93%) derived from the myelin-water component. Greater selectivity (approximately 96%) was found by extending the preparation to triple inversion-recovery, at the price of decreasing SNR by a factor of approximately 2. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text