Self-Aggregation Inhibits the Photonuclease Activity of Porphyrins
| Autor: | Yoshikazu Tomisugi, Yoshinobu Ishikawa, Katsumasa Aoki, Tadayuki Uno, Miyuki Oyama |
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| Rok vydání: | 2003 |
| Předmět: |
Circular dichroism
Deoxyribonucleases Photosensitizing Agents Porphyrins Stereochemistry Biological activity DNA General Chemistry General Medicine Cleavage (embryo) Porphyrin Chemical synthesis Solvent chemistry.chemical_compound chemistry Drug Discovery polycyclic compounds heterocyclic compounds Photosensitizer Protein Binding |
| Zdroj: | Chemical and Pharmaceutical Bulletin. 51:899-903 |
| ISSN: | 1347-5223 0009-2363 |
| Popis: | A series of tentacle porphyrins having four aminoalkyl groups at the periphery was synthesized, and the DNA binding properties were investigated by absorption and circular dichroism (CD) spectroscopic methods. The aminopropyl chain was found to facilitate binding, and bisignate induced CD spectra revealed that the porphyrins are self-stacked on the DNA surface. The photonuclease activity of the tentacle porphyrins was also studied, and the aminopropylporphyrin showed the highest activity. The activity increased in proportion to the porphyrin load, but higher loads resulted in the decrease of activity. This inhibitory step corresponded to aggregation of the porphyrin. Thus, the aggregation was suggested to shield the inner porphyrin from the solvent, the production of active oxygen species being suppressed. |
| Databáze: | OpenAIRE |
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