Perillyl Alcohol Attenuates NLRP3 Inflammasome Activation and Rescues Dopaminergic Neurons in Experimental In Vitro and In Vivo Models of Parkinson’s Disease

Autor:	Sahabuddin Ahmed, Samir Ranjan Panda, Mohit Kwatra, Bidya Dhar Sahu, VGM Naidu
Rok vydání:	2021
Předmět:	Mice Inflammasomes Physiology Dopaminergic Neurons Cognitive Neuroscience NLR Family Pyrin Domain-Containing 3 Protein Monoterpenes Animals Parkinson Disease Hydrogen Peroxide Cell Biology General Medicine Biochemistry
Zdroj:	ACS Chemical Neuroscience. 13:53-68
ISSN:	1948-7193
Popis:	NLRP3 activation plays a key role in the initiation and progression of a variety of neurodegenerative diseases. However, understanding the molecular mechanisms involved in the bidirectional signaling required to activate the NLRP3 inflammasomes is the key to treating several diseases. Hence, the present study aimed to investigate the role of lipopolysaccharide (LPS) and hydrogen peroxide (H
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e9e6d6dc5cccaabff20cd46649a417b https://doi.org/10.1021/acschemneuro.1c00550 Zobrazit plný text záznamu