Penicillamine-induced rapidly progressive glomerulonephritis in patients with progressive systemic sclerosis: successful treatment of two patients and a review of the literature
| Autor: | Sergio A. Jimenez, K. Adu Ntoso, Eric G. Neilson, John E. Tomaszewski |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent Biopsy Kidney Glomerulus Methylprednisolone Scleroderma Glomerulonephritis Medicine Rapidly progressive glomerulonephritis Humans Lupus Erythematosus Systemic skin and connective tissue diseases Proteinuria Lupus erythematosus Systemic lupus erythematosus Scleroderma Systemic business.industry Penicillamine Cystinuria medicine.disease Dermatology Nephrology Rheumatoid arthritis Immunology Female medicine.symptom business medicine.drug |
| Zdroj: | American journal of kidney diseases : the official journal of the National Kidney Foundation. 8(3) |
| ISSN: | 0272-6386 |
| Popis: | Although D-penicillamine has been used effectively in the management of a variety of diseases such as cystinuria, Wilson's disease, rheumatoid arthritis, and progressive systemic sclerosis, several toxic drug reactions have been observed with prolonged administration of this agent. One of the most serious side effects is the renal changes that occur following several months of use. We now report two patients with scleroderma who developed serologic evidence of lupus and crescentic glomerulonephritis during treatment with D-penicillamine. Both patients responded to pulse methylprednisolone and subsequent daily steroids. We also review the current information available on the variety of penicillamine nephropathies. |
| Databáze: | OpenAIRE |
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