Respiratory modulation of sympathetic nerve activity is enhanced in male rat offspring following uteroplacental insufficiency
| Autor: | Andrew M. Allen, Clément Menuet, Angelina Y. Fong, Mary E. Wlodek |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Pulmonary and Respiratory Medicine Bradycardia medicine.medical_specialty Sympathetic nervous system Sympathetic Nervous System Physiology Offspring Peripheral chemoreceptors Fetal Nutrition Disorders 030204 cardiovascular system & hematology Fetal Hypoxia Rats Inbred WKY Synaptic Transmission Tissue Culture Techniques Random Allocation 03 medical and health sciences 0302 clinical medicine Spontaneously hypertensive rat Internal medicine medicine Animals Respiratory system business.industry Respiration General Neuroscience Heart Neurogenic hypertension Chemoreceptor Cells Rats Disease Models Animal 030104 developmental biology Blood pressure medicine.anatomical_structure Endocrinology Hypertension medicine.symptom business Brain Stem |
| Zdroj: | Respiratory Physiology & Neurobiology. 226:147-151 |
| ISSN: | 1569-9048 |
| DOI: | 10.1016/j.resp.2015.11.008 |
| Popis: | Sympathetic nerve activity to the cardiovascular system displays prominent respiratory-related modulation which leads to the generation of rhythmic oscillations in blood pressure called Traube-Hering waves. An amplification of this respiratory modulation of sympathetic activity is observed in hypertension of both genetic, the spontaneously hypertensive rat, and induced, chronic intermittent hypoxia or maternal protein restriction during gestation, origin. Male offspring of mothers with uteroplacental insufficiency, induced by bilateral uterine vessel ligation at 18 days of gestation, are also hypertensive in adulthood. In this study we examined whether these male offspring display altered respiratory modulation of sympathetic activity at pre-hypertensive ages compared to controls. Respiratory, cardiovascular and sympathetic parameters were examined using the working heart-brainstem preparation in 35 day old male rats that had reduced birth weight due to uteroplacental insufficiency. Whilst all respiratory parameters were not different between groups, we observed an enhanced respiratory-related burst of thoracic sympathetic nerve activity and amplified Traube-Hering waves in the growth-restricted group. This group also showed an increased sympathetic and bradycardic response to activation of peripheral chemoreceptors. The observations add support to the view that altered respiratory modulation of sympathetic activity represents a common mechanism involved in the development of several forms of hypertension. |
| Databáze: | OpenAIRE |
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