Alteration of serum and tumoral neural cell adhesion molecule (NCAM) isoforms in patients with brain tumors

Autor:	Elisa Bal de Kier Joffé, Lydia Puricelli, Paola B. Campodónico, Eugenia Sacerdote de Lustig, Silvia Christiansen, José Lastiri, M. Guadalupe Pallotta, Laura B. Todaro, Mirta Varela
Rok vydání:	2006
Předmět:	Adult Male Cancer Research Pathology medicine.medical_specialty CIENCIAS MÉDICAS Y DE LA SALUD Lung Neoplasms Skin Neoplasms Brain tumor Uterine Cervical Neoplasms Medicina Clínica Biology Malignancy Statistics Nonparametric Oncología TISSULAR MARKER Western blot PUBLICACIONES Glioma medicine Biomarkers Tumor Humans Protein Isoforms NCAM SACERDOTE INVESTIGADORA Melanoma Neural Cell Adhesion Molecules Aged BRAIN TUMORS medicine.diagnostic_test SERUM MARKER Brain Neoplasms Gene Expression Profiling Brain Middle Aged medicine.disease Survival Analysis Gene Expression Regulation Neoplastic Neurology Oncology nervous system Case-Control Studies Biomarker (medicine) Neural cell adhesion molecule Female Neurology (clinical) Immunostaining Brain metastasis
Zdroj:	Journal of neuro-oncology. 83(2)
ISSN:	0167-594X
Popis:	The neural cell adhesion molecule (NCAM) is involved in the intercellular junctions of neurons and glial cells. We investigated its relevance as a biomarker in gliomas which main characteristic is their high invasiveness. We studied by Western blot the pattern of serum NCAM bands in patients with gliomas (n = 34), with brain metastasis of different primary cancers (n = 27) and with benign brain tumors (n = 22)] compared with healthy controls (n = 69). For densitometric analysis NCAM bands ≥130 kDa (HMW) and
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e9cc56c0776264712727bb5d91825df https://pubmed.ncbi.nlm.nih.gov/17216340 Zobrazit plný text záznamu Full text from SpringerLink