The roles of neuron-NG2 glia synapses in promoting oligodendrocyte development and remyelination
Autor: | Zhong-Xiang Yao, Rongrong Li, Mao Zhang, Pu Zhang |
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Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Histology Neurogenesis Oligodendrocyte progenitor Biology Pathology and Forensic Medicine Neuronal signaling 03 medical and health sciences 0302 clinical medicine medicine Animals Humans Antigens Remyelination Progenitor cell Neurons Stem Cells Multiple sclerosis Cell Differentiation Cell Biology medicine.disease Oligodendrocyte Oligodendroglia 030104 developmental biology medicine.anatomical_structure nervous system Synapses Proteoglycans Causal link Neuron Neuroglia Neuroscience 030217 neurology & neurosurgery |
Zdroj: | Cell and Tissue Research. 381:43-53 |
ISSN: | 1432-0878 0302-766X |
DOI: | 10.1007/s00441-020-03195-9 |
Popis: | NG2 immunopositive progenitor cells, also simply termed as NG2 glia and thought mainly to be oligodendrocyte precursor cells (OPCs), form synaptic connections with neurons in gray and white matters of brain. One of the most classical features of oligodendrocyte lineage cells is myelination, which will favor neuronal signaling transmission. Thus, is there a causal link between the specific synapses of neuron-NG2 glia and myelination? Building on this, here, we will discuss several relevant issues. First, in order to understand the synapses, it is necessary to integrate the definite inputs onto NG2 glia. We show that the synaptic activities and myelination are not synchronized, so the synapses are more likely to regulate early development of NG2 glia and prepare for myelination. Furthermore, several studies have suggested that the synapses also play a role in recovery of pathological conditions, such as multiple sclerosis (MS). Therefore, elucidating the activities of neuron-NG2 glia synapses will be beneficial for both physiological and pathological conditions. Graphical abstract The existence of neuron-NG2 glia synapses reveals that the neuronal activities projecting to NG2 glia is an elaborate regulation, and the signaling from neurons to NG2 glia is frequent in early stage. The neuron-NG2 glia synapses indirectly provide a basic condition to support myelination by extrasynaptic communication. The neuron-NG2 glia synapses also promote remyelination, and it occurs similar to physiological conditions. |
Databáze: | OpenAIRE |
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