Evidence of impaired microvascular function in pre-eclampsia: a non-invasive study

Autor:	PJ Steer, Mark R. Johnson, Suren R. Sooranna, J. Gamble, N. Anim-Nyame, Mhf Sullivan
Rok vydání:	2003
Předmět:	Oncotic pressure medicine.medical_specialty Endothelium biology medicine.diagnostic_test Diastole Albumin Gestational age General Medicine Hematocrit medicine.disease Preeclampsia medicine.anatomical_structure Endocrinology Neutrophil elastase Internal medicine medicine biology.protein
Zdroj:	Clinical Science. 104:405
ISSN:	1470-8736 0143-5221
DOI:	10.1042/cs20020323
Popis:	The clinical presentation of pre-eclampsia suggests that microvascular dysfunction may play a role in the maternal manifestations of the disease. Isovolumetric venous pressure (PVi) is an index of microvascular function, reflecting local plasma colloid osmotic (oncotic) pressure, and is abnormal in clinical conditions with microvascular dysfunction. We hypothesized that, in pre-eclampsia, post-capillary margination of neutrophils would increase post-capillary resistance, and therefore PVi. A small cumulative step strain-gauge plethysmography protocol was used to compare PVi in 18 women with pre-eclampsia, 16 normal pregnant women and 17 non-pregnant controls. Circulating levels of vascular cell-adhesion molecule-1 (VCAM-1), intercellular cell-adhesion molecule-1 (ICAM-1) and E-selectin, and neutrophil elastase, were measured to assess endothelial and neutrophil activation respectively. PVi was significantly greater in the pre-eclampsia group, relative to the normal pregnant and non-pregnant controls (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e91f310ad78681f6e4004ebf6ba253c https://doi.org/10.1042/cs20020323 Zobrazit plný text záznamu